Riboflavin is an antioxidant: a review update

Aerobic organisms need antioxidant defense systems to deal with free radicals which either are produced during aerobic respiration or may have an external origin. Oxidative stress, which is resulted from an imbalance between the production of free radicals and the ability of antioxidant defense mech...

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Bibliographic Details
Published in:British journal of nutrition 2022-11, Vol.128 (10), p.1887-1895
Main Authors: Olfat, Nafisa, Ashoori, Marziyeh, Saedisomeolia, Ahmad
Format: Article
Language:English
Subjects:
Aerobic respiration
Alzheimer's disease
Antibiotics
Antioxidants
Antioxidants - metabolism
Apoptosis
Biomarkers
Chronic illnesses
Diabetes mellitus
DNA damage
Drug resistance
Enzymes
Free Radicals
Gene expression
Inflammation
Inflammatory bowel disease
Irradiation
Lipid Peroxidation
Liver
Metabolism
Molecular Nutrition
Neurodegenerative diseases
Oxidative stress
Oxidative Stress - physiology
Photocatalysis
Proteins
Riboflavin
Riboflavin - metabolism
Rodents
Ultraviolet radiation
Vitamin B
Vitamin C
Vitamin E
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Summary:Aerobic organisms need antioxidant defense systems to deal with free radicals which either are produced during aerobic respiration or may have an external origin. Oxidative stress, which is resulted from an imbalance between the production of free radicals and the ability of antioxidant defense mechanism to deactivate them, is involved in the development of many chronic diseases such as cancer, diabetes, CVD and some neurodegenerative diseases. Reinforcing the antioxidant potential of the body has been considered as a strategy that could prevent and manage such conditions. In the previous review article published by British Journal of Nutrition, in 2014, for the first time, we concluded that riboflavin could alleviate oxidative stress. Although riboflavin can serve as a prooxidant when exposed to ultraviolet irradiation, the literature is replete with studies that support its antioxidant properties. Furthermore, recent evidence suggests that riboflavin may have a therapeutic potential in many conditions in which oxidative stress is involved, although the therapeutic efficacy of riboflavin as an antioxidant requires further study under conditions of wellness and clinical disease.
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114521005031