Predictors of anti‐VEGF efficacy in chronic central serous chorioretinopathy based on intraocular cytokine levels and pigment epithelium detachment subtypes

Purpose The aim of this study was to compare intraocular cytokines among different types of pigment epithelial detachments (PEDs) in patients with chronic central serous chorioretinopathy (CSC) and to investigate the association of cytokine levels and PED types with response to anti‐vascular endothe...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2022-11, Vol.100 (7), p.e1385-e1394
Main Authors: Mao, Jianbo, Zhang, Caiyun, Zhang, Shian, Liu, Chenyi, Chen, Nuo, Tao, Jiwei, She, Xiangjun, Zheng, Zicheng, Lv, Zhe, Shen, Lijun
Format: Article
Language:English
Subjects:
Acuity
central serous chorioretinopathy
conbercept
cytokine
Cytokines
Epithelium
Interferon
Interleukin 6
Monocyte chemoattractant protein
Monocytes
optical coherence tomography
Patients
Vascular endothelial growth factor
Vascularization
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Summary:Purpose The aim of this study was to compare intraocular cytokines among different types of pigment epithelial detachments (PEDs) in patients with chronic central serous chorioretinopathy (CSC) and to investigate the association of cytokine levels and PED types with response to anti‐vascular endothelial growth factor (VEGF) therapy. Methods We included 88 patients with chronic CSC and 30 controls. The anti‐VEGF agent conbercept was given intravitreally to chronic CSC patients. Cytokines VEGF, interleukin‐6 (IL‐6), IL‐8, IL‐10, interferon‐inducible protein‐10 and monocyte chemoattractant protein‐1 in aqueous humour were measured. Treatment efficacy, cytokine levels, changes in best‐corrected visual acuity (BCVA) and optical coherence tomography parameters were assessed at baseline and 1 month after treatment. Results Patients were divided into three groups: flat irregular PED (FIPED) with choroidal neovascularization (CNV), FIPED without CNV and focal PED. Vascular endothelial growth factor (VEGF) was the only cytokine significantly higher in chronic CSC FIPED patients. There were no significant differences in VEGF between FIPED patients with or without CNV (p = 0.234). At 1 month after conbercept injection, treatment effective rates in FIPED patients with or without CNV were significantly higher than in patients with focal PED (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.15109