Self-Assembled Nanostructures from Amphiphilic Sucrose-Soyates for Solubilizing Hydrophobic Guest Molecules

We studied self-assembly and colloidal properties of poly­(ethylene glycol) (pEG) conjugated sucrose soyate polyols (PSSP). These molecular platforms were synthesized by covalently connecting PEGs of different molecular weights (M n) (12 and 16 ethylene oxide units) to epoxidized sucrose soyate (ESS...

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Bibliographic Details
Published in:Langmuir 2022-02, Vol.38 (6), p.2066-2075
Main Authors: Bansal, Karan, Webster, Dean, Quadir, Mohiuddin
Format: Article
Language:English
Subjects:
Hydrophobic and Hydrophilic Interactions
Micelles
Nanostructures - chemistry
Polyethylene Glycols - chemistry
Sucrose
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Summary:We studied self-assembly and colloidal properties of poly­(ethylene glycol) (pEG) conjugated sucrose soyate polyols (PSSP). These molecular platforms were synthesized by covalently connecting PEGs of different molecular weights (M n) (12 and 16 ethylene oxide units) to epoxidized sucrose soyate (ESS). The synthesized PSSP products showed amphiphilicity, reduced water surface tension, and exhibited critical Aggregation Concentration (CAC) within the range of 0.3–0.4 mg/mL. We observed that PSSP self-assembles in water in the form of nanoparticles without the need of any cosolvents. These nanoparticles exhibited number-average hydrodynamic diameter of 120 ± 8 nm with a polydispersity index (PDI) of
ISSN:0743-7463
1520-5827
1520-5827
DOI:10.1021/acs.langmuir.1c03033