What Should Be Responsible for Eryptosis in Chronic Kidney Disease?

Background: Renal anemia is an important complication of chronic kidney disease (CKD). In addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the impact of eryptosis on renal anemia demands attention. However, a systemic analysis concerning the pathophysiology of...

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Bibliographic Details
Published in:Kidney & blood pressure research 2022-06, Vol.47 (6), p.375-390
Main Authors: Li, Dongxin, Zheng, Xujuan, Zhang, Yunxia, Li, Xiangling, Chen, Xuexun, Yin, Yonghua, Hu, Jingwen, Li, Jialin, Guo, Min, Wang, Xiangming
Format: Article
Language:English
Subjects:
Anemia
Anemia - etiology
Apoptosis
Cell cycle
Cell death
Cytoskeleton
Eryptosis
Erythrocytes
Erythrocytes - metabolism
Erythropoiesis
Erythropoietin
Hemodialysis
Homeostasis
Humans
Iron
Iron deficiency
Kidney diseases
Kidneys
Kinases
Life span
Mortality
Nutrient deficiency
Osmosis
Osmotic stress
Oxidative stress
Pathophysiology
Peritoneal dialysis
Phosphatidylserine
Plasma
Proteins
Quality of life
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - metabolism
Review Article
Therapeutic targets
Toxins
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Summary:Background: Renal anemia is an important complication of chronic kidney disease (CKD). In addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the impact of eryptosis on renal anemia demands attention. However, a systemic analysis concerning the pathophysiology of eryptosis has not been expounded. Summary: The complicated conditions in CKD patients, including oxidative stress, osmotic stress, metabolic stress, accumulation of uremic toxins, and iron deficiency, affect the normal skeleton structure of red blood cells (RBCs) and disturbs ionic homeostasis, causing phosphatidylserine to translocate to the outer lobules of the RBC membrane that leads to early elimination and/or shortening of the RBC lifespan. Inadequate synthesis of RBCs cannot compensate for their accelerated destruction, thus exacerbating renal anemia. Meanwhile, EPO treatment alone will not reverse renal anemia. A variety of eryptosis inhibitors have so far been found, but evidence of their effectiveness in the treatment of CKD remains to be established. Key Messages: In this review, the pathophysiological processes and factors influencing eryptosis in CKD were elucidated. The aim of this review was to underline the importance of eryptosis in renal anemia and determine some promising research directions or possible therapeutic targets to correct anemia in CKD.
ISSN:1420-4096
1423-0143
DOI:10.1159/000522133