Expression and prognostic analysis of STAT6(YE361) in Hodgkin lymphoma

This study aimed to investigate the expression and prognostic significance of the signal transducer and activator of transcription protein 6 (STAT6YE361) and EB virus encoding a small molecule RNA (EBER) in Hodgkin lymphoma (HL), as well as their correlation with clinical parameters. The expression...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2022-03, Vol.231, p.153781-153781, Article 153781
Main Authors: Yang, Liu-qing, Wang, Lei, Zuo, Li-ke, Ma, Zhi-ping, Yan, Shu-fang, Yang, Mei-hong, Liu, Bo, Li, Xin-xia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Chi-Square Distribution
Child
Child, Preschool
Differential diagnosis
EBER
Female
Gene Expression - genetics
Gene Expression - physiology
Hodgkin Disease - diagnosis
Hodgkin Disease - genetics
Hodgkin lymphoma
Humans
Immunohistochemistry - methods
Immunohistochemistry - statistics & numerical data
Male
Middle Aged
Prognosis
Prognostic analysis
Proportional Hazards Models
STAT6
STAT6 Transcription Factor - analysis
STAT6 Transcription Factor - genetics
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Summary:This study aimed to investigate the expression and prognostic significance of the signal transducer and activator of transcription protein 6 (STAT6YE361) and EB virus encoding a small molecule RNA (EBER) in Hodgkin lymphoma (HL), as well as their correlation with clinical parameters. The expression of STAT6YE361 and EBER was investigated in HL via immunohistochemistry and in situ hybridization. Patient clinical data were retrospectively collected from archival libraries, and statistical analysis was performed. Overall, the nuclear positive expression rate of STAT6YE361 was 46%, and the EBER positive expression rate was 57%. STAT6YE361 was specifically expressed on the nucleus in cHL tissues. EBER was overexpressed in HL and had correlations with several clinical data, including age, gender, ethnicity, and primary cancer site. Interestingly, nuclear STAT6YE361 expression was correlated with EBER expression. Based on survival analysis, the nuclear expression of STAT6YE361 and female patients were associated with poor prognosis and were independent prognostic factors for five-year OS. These findings suggest that STAT6YE361 is a potential valuable index in the differential diagnosis and prognosis of HL. The mechanism of STAT6YE361 is related to Epstein-Barr virus infection.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2022.153781