Photodynamic therapy-mediated extirpation of cutaneous-resistant dermatophytosis with Ag@ZnO nanoparticles: an efficient therapeutic approach for onychomycosis

The aim of this study was to determine whether photodynamic therapy of resistant onychomycosis with Ag@ZnO nanoparticles can promote the treatment procedure and extirpates the recurrence of fungal infection. Ag@ZnO nanoparticles (NPs) under UVB-radiation were applied to treat and through photodynami...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2022-02, Vol.17 (4), p.219-236
Main Authors: Ghaemi, Behnaz, Hashemi, Seyed Jamal, Kharrazi, Sharmin, Moshiri, Arfa, Kargar Jahromi, Hossein, Amani, Amir
Format: Article
Language:English
Subjects:
Ag@ZnO nanoparticles
dermatophytes
Humans
Metal Nanoparticles - therapeutic use
Nanoparticles
onychomycosis
Onychomycosis - drug therapy
Onychomycosis - microbiology
Photochemotherapy
photodynamic therapy
ROS
Tissue Distribution
Zinc Oxide - therapeutic use
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Summary:The aim of this study was to determine whether photodynamic therapy of resistant onychomycosis with Ag@ZnO nanoparticles can promote the treatment procedure and extirpates the recurrence of fungal infection. Ag@ZnO nanoparticles (NPs) under UVB-radiation were applied to treat and through photodynamic therapy. therapeutic efficacy, biocompatibility and biodistribution of Ag@ZnO NPs were studied. 40 μg/ml of UVB-activated Ag@ZnO NPs showed 100% antifungal activity against dermatophytosis and followed by complete growth prevention by degeneration of spores and mycelium after 180 days, while posed biocompatibility. This study showed the superiority of photodynamic therapy with Ag@ZnO NPs followed by proper regeneration of the skin with Zinc ion of the shell.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2021-0138