Relation of serum heart type fatty acid binding protein to left ventricular diastolic dysfunction in patients with type 2 diabetes and early diabetic kidney disease

• Published in: Journal of diabetes and its complications 2022-03, Vol.36 (3), p.108122-108122, Article 108122
• Main Authors: Abdelaaty, Talaat, Morsy, Eman, Rizk, Mohamed, Shokry, Ahmed, Abdelhameid, Ahmed, Fathalla, Reem
• Format: Article
• Language: English
• Subjects: Albuminuria - complications; Blood pressure; Body mass index; Cardiac stress tests; Cardiovascular disease; Cholesterol; Creatinine; Diabetes; Diabetes Mellitus, Type 2; Diabetic kidney disease; Diabetic Nephropathies - complications; Diabetic Nephropathies - diagnosis; Diabetic nephropathy; Diastolic dysfunction; Ejection fraction; Fatty Acid Binding Protein 3; Fatty acids; Heart attacks; Heart type fatty acid binding protein; Humans; Hyperglycemia; Hypertension; Kidney diseases; Proteins; Type 2 diabetes; Uric acid; Ventricular Dysfunction, Left - complications
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2021.108122

We aimed to investigate the serum level of heart type fatty acid binding protein (H-FABP) and its relation to left ventricular (LV) diastolic dysfunction in patients with type 2 diabetes (T2DM) and early diabetic kidney disease (DKD). This study was conducted on 100 T2DM patients divided into 50 patients with early DKD and 50 patients without DKD. Doppler echocardiography was used to assess LV function and serum H-FABP levels were measured using ELISA technique. 78% of patients with DKD and 12% of patients without DKD had LV diastolic dysfunction. Among patients with DKD, those with diastolic dysfunction had significantly higher urinary albumin to creatinine ratio (UACR) (p = 0.041). H-FABP levels were significantly higher in patients with DKD (p˂0.001) and it had significant positive correlation with UACR (p = 0.009). No significant difference was found regarding serum H-FABP levels between patients with normal LV function and those with diastolic dysfunction in both study groups. Diastolic dysfunction is a common finding among patients with T2DM. UACR, but not serum H-FABP, is significantly associated with diastolic dysfunction in patients with early DKD. Serum H-FABP level is significantly higher in early DKD and positively correlated with the level of albuminuria. •LV diastolic dysfunction is significantly prevalent in patients with early DKD.•Higher ACR levels were found in DKD patients with diastolic dysfunction.•Higher serum levels of H.FABP were detected in patients with early DKD.•No significant association was found between H-FABP and LV diastolic dysfunction.