The effectiveness of radiotherapy in preventing disease recurrence after breast cancer surgery

• Published in: Surgical oncology 2022-05, Vol.41, p.101709-101709, Article 101709
• Main Authors: Luz, Felipe Andrés Cordero da, Marinho, Eduarda da Costa, Nascimento, Camila Piqui, Marques, Lara de Andrade, Duarte, Mateus Bringel Oliveira, Delfino, Patrícia Ferreira Ribeiro, Antonioli, Rafael Mathias, Araújo, Rogério Agenor de, Silva, Marcelo José Barbosa
• Format: Article
• Language: English
• Subjects: Ablation; Antineoplastic agents; Breast cancer; Breast Neoplasms - radiotherapy; Breast Neoplasms - surgery; Cancer surgery; Cancer therapies; Chemotherapy; Endocrine therapy; Ethics; Female; Histology; Humans; Lymphatic system; Margins of Excision; Mastectomy; Medical prognosis; Metastases; Metastasis; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Patients; Prognosis; Radiation therapy; Radiotherapy; Radiotherapy, Adjuvant; Retrospective Studies; Risk; Survival analysis; Tumors
• ISSN: 0960-7404; 1879-3320
• DOI: 10.1016/j.suronc.2022.101709

The locoregional management of breast cancer has a critical impact on prognosis. This study aimed to analyze the effectiveness of radiotherapy against the deleterious effect of positive surgical margins on disease outcomes. Retrospective, single-center study enrolled 721 breast cancer patients with a median follow-up of approximately 64.50 months (3.67–247.40). Analyses were performed considering the end of adjuvant therapy, except endocrine therapy. Kaplan-Meier and Cox regression were performed to obtain the predictive value of treatments. The minimally adequate radiotherapy (≥45 cGy) was associated with improved outcomes in breast cancer patients compared to inadequate radiotherapy (