Two cases of pineal anlage tumor with molecular analysis

Pineal anlage tumor is a rare pediatric tumor with clinical and histological features overlapping with pineoblastoma. Two patients with pineal anlage tumor, a 13‐month‐old female and an 11‐month‐old male, underwent subtotal resection, high‐dose chemotherapy with autologous stem cell rescue, and radi...

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Bibliographic Details
Published in:Pediatric blood & cancer 2022-04, Vol.69 (4), p.e29596-n/a
Main Authors: Scherpelz, Kathryn P., Crotty, Erin E., Paulson, Vera A., Lockwood, Christina M., Leary, Sarah E. S., Ellenbogen, Richard G., Lee, Amy, Ermoian, Ralph P., Vitanza, Nicholas A., Cole, Bonnie L.
Format: Article
Language:English
Subjects:
Autografts
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Chemotherapy
Child
Chromosome Aberrations
copy number variant
Female
Hematology
Humans
Infant
Male
molecular analysis
Mutation
Neoplasia
Oncology
pediatric pineal neoplasm
Pediatrics
pineal anlage tumor
Pineal gland
Pineal Gland - pathology
Pinealoma - genetics
Pinealoma - pathology
Pinealoma - therapy
pineoblastoma
Stem cells
Supratentorial Neoplasms - pathology
Tumors
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Summary:Pineal anlage tumor is a rare pediatric tumor with clinical and histological features overlapping with pineoblastoma. Two patients with pineal anlage tumor, a 13‐month‐old female and an 11‐month‐old male, underwent subtotal resection, high‐dose chemotherapy with autologous stem cell rescue, and radiation. Neither had tumor progression 50 months after diagnosis. The tumors underwent next‐generation sequencing on a panel of 340 genes. Chromosomal copy gains and losses were present and differed between the tumors. No mutations or amplifications, including none specific to pineoblastoma, were identified.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.29596