Action of Matricaria recutita (chamomile) in the management of radiochemotherapy oral mucositis: A systematic review

The objective of this study was to evaluate the effect of topical chamomile in the prevention and/or treatment of oral mucositis (OM) in cancer patients. It was a systematic review, which sought articles of the randomized clinical trial according to the PRISMA parameters, registered in the PROSPERO....

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Bibliographic Details
Published in:Phytotherapy research 2022-03, Vol.36 (3), p.1115-1125
Main Authors: de Lima Dantas, Juliana Borges, Freire, Tila Fortuna Costa, Sanches, Ana Carla Barletta, Julião, Erielma Lomba Dias, Medrado, Alena Ribeiro Alves Peixoto, Martins, Gabriela Botelho
Format: Article
Language:English
Subjects:
Chamomile
Chemoradiotherapy
chemotherapy
Humans
Matricaria
Mucositis
oral mucositis
Patients
Phytotherapy
Plant Extracts - pharmacology
Prevention
radiotherapy
Randomized Controlled Trials as Topic
Stomatitis - chemically induced
Stomatitis - drug therapy
Systematic review
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Summary:The objective of this study was to evaluate the effect of topical chamomile in the prevention and/or treatment of oral mucositis (OM) in cancer patients. It was a systematic review, which sought articles of the randomized clinical trial according to the PRISMA parameters, registered in the PROSPERO. The databases used were PubMed, Cochrane Library, and Bireme. Descriptors were selected from DeCs/MeSH and the PICO strategy was applied. The search found 148 publications. After all the steps, six articles were selected. The total sample included 492 patients and all studies used the same OM measurement scale. The results showed that the application of topical chamomile was effective in the prevention and/or treatment of OM in four of the six studies, with a dose ranging from 1% to 2.5% and duration that ranged from single to 4 times a day. Some limitations were observed: the minimum age of the patients was not informed, and there was no specification of the sites involved or the chemotherapies used. The application of topical chamomile in the preventive/therapeutic of chemo‐induced OM seems to be recommended. In addition, scientific production should be encouraged, as it aims to determine useful protocols for this phytotherapy for the oncology population.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7378