Hemodynamic performance of INSPIRIS RESILIA aortic bioprosthesis for severe aortic stenosis: 2-year follow-up in Japanese cohort

• Published in: Journal of artificial organs 2022-12, Vol.25 (4), p.323-328
• Main Authors: Fukunaga, Naoto, Yoshida, Soshi, Shimoji, Akio, Maeda, Toshi, Mori, Otohime, Yoshizawa, Kosuke, Okada, Tatsuji, Tamura, Nobushige
• Format: Article
• Language: English
• Subjects: Aorta; Aortic stenosis; Aortic valve; Biomedical Engineering and Bioengineering; Cardiac Surgery; Congestive heart failure; Durability; Heart failure; Heart valves; Hemodynamics; Medicine; Medicine & Public Health; Nephrology; Orifices; Original Article; Patients; Pericarditis; Pressure gradients; Ventricle
• ISSN: 1434-7229; 1619-0904
• DOI: 10.1007/s10047-022-01316-5

The INSPIRIS RESILIA aortic bioprosthesis (Edwards Lifesciences LLC, Irvine, USA) was fixed in novel tissue preservation technology to ensure long-term durability. Hemodynamic performance after aortic valve replacement (AVR) for severe aortic stenosis (AS) has not been published in the Japanese cohort. Twenty-nine patients underwent AVR with INSPIRIS RESILIA bioprosthesis for severe AS between November 1, 2018 and December 31, 2020. The mean age was 75.1 ± 4.5 years with 19 female patients. Body surface area was 1.58 ± 0.19 m 2 and New York Heart Association functional class was 2.2 ± 0.5. Hemodynamic performance was assessed using follow-up transthoracic echocardiographic data collected at 3–6 months, 1 year and 2 years. The mean follow-up time was 19.2 ± 7.2 months, with a 100% follow-up rate. One patient died of postoperative heart failure. The preoperative mean and peak transvalvular pressure gradients (PGs) were 51.9 ± 18.4 mmHg and 89.3 ± 34.9 mmHg, respectively, and effective orifice area 0.72 ± 0.26 cm 2 . They improved at 10.2 ± 3.5 mmHg ( p