Recent advances in the total synthesis of 2,7′-cyclolignans

The synthetic progress of bioactive 2,7′-cyclolignans is reviewed. After a short introduction to biosynthesis and chemoenzymatic synthesis, the chemical synthesis of various aryltetralin, dihydronaphthalene and 7′-arylnaphthalene-types of these lignans is demonstrated. Notably, newly developed metho...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-02, Vol.2 (8), p.1623-1636
Main Authors: Zhang, Han-Qiu, Yan, Chu-Xuan, Xiao, Jian, Wang, Ya-Wen, Peng, Yu
Format: Article
Language:English
Subjects:
Biological Products - chemical synthesis
Biological Products - chemistry
Biosynthesis
Catalysis
Chemical synthesis
Light
Lignans
Lignans - chemical synthesis
Lignans - chemistry
Molecular Structure
Natural products
Palladium - chemistry
Stereoisomerism
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Summary:The synthetic progress of bioactive 2,7′-cyclolignans is reviewed. After a short introduction to biosynthesis and chemoenzymatic synthesis, the chemical synthesis of various aryltetralin, dihydronaphthalene and 7′-arylnaphthalene-types of these lignans is demonstrated. Notably, newly developed methods, such as Pd-catalyzed C-H arylation, organocatalysis and photocatalysis under visible-light, are discussed during the construction of their skeleton. These efforts will stimulate further development of novel synthetic strategies for this kind of natural product with important biological activities. Diverse strategies for the chemical synthesis and biosynthesis of 2,7′-cyclolignan natural products are reviewed.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02457d