Arenga westerhoutii Griff.: bioactive constituents, nutraceuticals, antioxidant and anti-diabetic potential of stem extract and an insight into molecular docking analysis

Herein, we reported a systematic scientific study of Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75....

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Bibliographic Details
Published in:Natural product research 2023-07, Vol.37 (13), p.2293-2297
Main Authors: Borah, Nirangkush, Chetia, Pankaj, Tamuly, Chandan
Format: Article
Language:English
Subjects:
Antioxidants
Assaying
Bioactive compounds
Biological activity
Chlorogenic acid
Diabetes mellitus
Epicatechin
Ferulic acid
Functional foods & nutraceuticals
Glucosidase
High-performance liquid chromatography
Liquid chromatography
Molecular docking
α-Glucosidase
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Summary:Herein, we reported a systematic scientific study of Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75.67 ± 0.05, 38.19 ± 0.10 and 13.11 ± 0.02 µg/mL of chlorogenic acid, ferulic acid and epicatechin respectively in 1 mg/ml of the extract. 50% MeOH hydro-alcoholic extract was found to show lowest IC value in both antioxidant (IC = 2.925 ± 0.12 µg/mL, DPPH assay) and anti-diabetic assays (IC = 18.03 ± 0.18 µg/mL, α-glucosidase assay). Further analysis by molecular docking study suggested the interaction of components towards α-glucosidase enzyme.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2037085