Loading…

CD68 and CD83 immune populations in non-metastatic axillary lymph nodes are of prognostic value for the survival and relapse of breast cancer patients

Background The foremost cause of death of breast cancer (BC) patients is metastasis, and the first site to which BC predominantly metastasizes is the axillary lymph node (ALN). Thus, ALN status is a key prognostic indicator at diagnosis. The immune system has an essential role in cancer progression...

Full description

Saved in:
Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2022-07, Vol.29 (4), p.618-635
Main Authors: López, Carlos, Bosch, Ramón, Korzynska, Anna, García-Rojo, Marcial, Bueno, Gloria, García-Fontgivell, Joan Francesc, Martínez González, Salomé, Gras Navarro, Andrea, Sauras Colón, Esther, Casanova Ribes, Júlia, Roszkowiak, Lukasz, Mata, Daniel, Arenas, Meritxell, Gómez, Junior, Roso, Albert, Berenguer, Marta, Reverté-Villarroya, Silvia, Llobera, Montserrat, Baucells, Jordi, Lejeune, Marylène
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The foremost cause of death of breast cancer (BC) patients is metastasis, and the first site to which BC predominantly metastasizes is the axillary lymph node (ALN). Thus, ALN status is a key prognostic indicator at diagnosis. The immune system has an essential role in cancer progression and dissemination, so its evaluation in ALNs could have significant applications. In the present study we aimed to investigate the association of clinical-pathological and immune variables in the primary tumour and non-metastatic ALNs (ALNs – ) of a cohort of luminal A and triple-negative BC (TNBC) patients with cancer-specific survival (CSS) and time to progression (TTP). Methods We analysed the differences in the variables between patients with different outcomes, created univariate and multivariate Cox regression models, validated them by bootstrapping and multiple imputation of missing data techniques, and used Kaplan–Meier survival curves for a 10-years follow-up. Results We found some clinical-pathological variables at diagnosis (tumour diameter, TNBC molecular profile and presence of ALN metastasis), and the levels of several immune markers in the two studied sites, to be associated with worse CSS and TTP. Nevertheless, only CD68 and CD83 in ALNs – were confirmed as independent prognostic factors for TTP. Conclusions The study identified the importance of macrophage and dendritic cell markers as prognostic factors of relapse for BC. We highlight the importance of studying the immune response in ALNs – , which could be relevant to the prediction of BC patients’ outcome.
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-022-01336-2