A study of the immunohistochemical profile of bladder cancer in neuro-urological patients by the French Association of Urology

Purpose To establish whether the expression of markers of cell differentiation (CK7, CK14, CK20, GATA3), apoptosis (p53), proliferation (Ki67, STAG2) and peri-tumoural lymphocytes (CD3, CD8), provides specific information about urothelial carcinogenesis in neuro-urological patients with bladder canc...

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Bibliographic Details
Published in:World journal of urology 2022-08, Vol.40 (8), p.1939-1947
Main Authors: Michel, Floriane, Cancrini, Fabiana, Cancel-Tassin, Géraldine, Gamé, Xavier, Huyghe, Eric, Rock, Aurélien, Léon, Grégoire, Uzan, Audrey, Desfemmes, François-Régis, Peyronnet, Benoît, Fallot, Jérémy, Léon, Priscilla, Rolland, Emmanuel, Perrouin-Verbe, Marie-Aimée, Wodey, Jacques, Capon, Grégoire, Karsenty, Gilles, Rouprêt, Morgan, Cussenot, Olivier, Alshehhi, Hussa, Comperat, Eva, Phé, Véronique
Format: Article
Language:English
Subjects:
Apoptosis
Bladder cancer
Cancer
Carcinogenesis
CD3 antigen
CD8 antigen
Cell differentiation
GATA-3 protein
Immunohistochemistry
Invasiveness
Lymphocytes
Medicine
Medicine & Public Health
Nephrology
Oncology
Squamous cell carcinoma
Topic Paper
Urology
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Summary:Purpose To establish whether the expression of markers of cell differentiation (CK7, CK14, CK20, GATA3), apoptosis (p53), proliferation (Ki67, STAG2) and peri-tumoural lymphocytes (CD3, CD8), provides specific information about urothelial carcinogenesis in neuro-urological patients with bladder cancer (NBC). Methods Tissue samples from NBC were retrieved from 15 centres in France and compared to control samples from non neuro-urological patients with bladder cancer (NNBC) and from neuro-urological patients without bladder cancer (NB). The expression of CK7, CK14, CK20, GATA3, p53, Ki67, STAG2, CD3 and CD8 markers was analysed using immunohistochemistry of tissue microarray sections. Results Overall, tissue samples from 124 patients were included in the study ( n  = 72 NBC, n  = 26 NNBC and n  = 26 NB). Muscle invasive bladder cancer (MIBC) was found in 52 NBC patients (72.2%) and squamous cell differentiation in 9 (12.5%). In NBC samples, the expression of CK20 and GATA3 was significantly more frequent in NMIBC compared to MIBC ( p  = 0.015 and p  = 0.004, respectively). CK20 and GATA3 were significantly more expressed in NBC compared to NNBC ( p  
ISSN:1433-8726
0724-4983
1433-8726
DOI:10.1007/s00345-022-03942-3