Loading…
Copper-catalyzed direct sulfenoamination of saturated ketones via in situ formed enaminones
A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed using copper-TEMPO systems. This reaction features a broad substrate scope to afford the desired product in good to excellent yields with high stereoselectivity. A preliminary mechanistic study suggest...
Saved in:
Published in: | Organic & biomolecular chemistry 2022-02, Vol.20 (8), p.1749-1753 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed using copper-TEMPO systems. This reaction features a broad substrate scope to afford the desired product in good to excellent yields with high stereoselectivity. A preliminary mechanistic study suggests that the
formed enaminone acts as the key intermediate. |
---|---|
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/d1ob02469h |