Loading…

Copper-catalyzed direct sulfenoamination of saturated ketones via in situ formed enaminones

A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed using copper-TEMPO systems. This reaction features a broad substrate scope to afford the desired product in good to excellent yields with high stereoselectivity. A preliminary mechanistic study suggest...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-02, Vol.20 (8), p.1749-1753
Main Authors: Wang, Jiateng, Zhuang, Yunqing, Zhao, Jie, Bi, Yusong, Li, Chunyan, Bi, Gehua, Yang, Kai, Huang, Xin, Zhang, Weimin
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed using copper-TEMPO systems. This reaction features a broad substrate scope to afford the desired product in good to excellent yields with high stereoselectivity. A preliminary mechanistic study suggests that the formed enaminone acts as the key intermediate.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02469h