Bone remodeling following mandibular reconstruction using fibula free flap

To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free...

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Bibliographic Details
Published in:Journal of biomechanics 2022-03, Vol.133, p.110968-110968, Article 110968
Main Authors: Zheng, Keke, Yoda, Nobuhiro, Chen, Junning, Liao, Zhipeng, Zhong, Jingxiao, Wu, Chi, Wan, Boyang, Koyama, Shigeto, Sasaki, Keiichi, Peck, Christopher, Swain, Michael, Li, Qing
Format: Article
Language:English
Subjects:
Algorithms
Apposition
Biomechanics
Bone density
Bone Remodeling
Bone remodelling
Bone Transplantation
Fibula
Fibula - surgery
Free Tissue Flaps - surgery
Humans
Mandible
Mandible - physiology
Mandible - surgery
Mandibular Reconstruction - methods
Maxillofacial
Maxillofacial reconstruction
Medical imaging
Morphology
Patients
Placement design of fixation plate
Reconstruction
Reconstructive Surgical Procedures - methods
Retrospective Studies
Surgery
Time-dependent remodelling algorithm. Clinical follow-up
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Summary:To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2022.110968