Dynamics of recent thymic emigrants in pediatric recipients of allogeneic hematopoetic stem cell transplantation

After allogeneic hematopoietic stem cell transplantation (allo-HSCT), the recurrence of recent thymic emigrants (RTE) and self-tolerant T cells indicate normalized thymic function. From 2008 to 2019, we retrospectively analyzed the RTE-reconstitution rate and the minimal time to reach normal age-spe...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2022-04, Vol.57 (4), p.620-626
Main Authors: Drozdov, Daniel, Petermann, Katrin, Dougoud, Svetlana, Oberholzer, Sibylle, Held, Leonhard, Güngör, Tayfun, Hauri-Hohl, Mathias
Format: Article
Language:English
Subjects:
631/250/1904
631/532/1542
Age
Busulfan
Busulfan - therapeutic use
CD4 antigen
CD45RA antigen
Cell Biology
Child
Graft versus host disease
Graft vs Host Disease
Graft-versus-host reaction
Hematology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Internal Medicine
Lymphocytes
Lymphocytes T
Medicine
Medicine & Public Health
Pediatrics
Public Health
Retrospective Studies
Stem cell transplantation
Stem Cells
T-Lymphocytes
Thymus
Thymus Gland
Transplantation
Transplantation Conditioning
Transplantation, Homologous
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Summary:After allogeneic hematopoietic stem cell transplantation (allo-HSCT), the recurrence of recent thymic emigrants (RTE) and self-tolerant T cells indicate normalized thymic function. From 2008 to 2019, we retrospectively analyzed the RTE-reconstitution rate and the minimal time to reach normal age-specific first percentiles for CD31 + CD45RA + CD4 + T cells in 199 pediatric patients after allo-HSCT for various malignant and non-malignant diseases. The impact of clinically significant graft-versus-host disease (GvHD), age at transplantation, underlying disease and cumulative area under the curve of busulfan on RTE-reemergence was assessed in multivariable longitudinal analysis. RTE-reconstitution (coefficient −0.24, 95% CI −0.33 to −0.14, p  
ISSN:0268-3369
1476-5365
1476-5365
DOI:10.1038/s41409-022-01594-w