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Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure
The combined effects of copper and polyvinyl chloride (PVC) microparticles were investigated on the metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The fish were exposed to 0.25 mg/L copper and/or 0.5 mg/L PVC microparticles over a 14-d period...
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| Published in: | Marine pollution bulletin 2022-02, Vol.175, p.113401-113401, Article 113401 |
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| container_end_page | 113401 |
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| container_start_page | 113401 |
| container_title | Marine pollution bulletin |
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| creator | Hoseini, Seyyed Morteza Khosraviani, Kave Hosseinpour Delavar, Fatemeh Arghideh, Mohammad Zavvar, Fatemeh Hoseinifar, Seyed Hossein Van Doan, Hien Zabihi, Erfan Reverter, Miriam |
| description | The combined effects of copper and polyvinyl chloride (PVC) microparticles were investigated on the metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The fish were exposed to 0.25 mg/L copper and/or 0.5 mg/L PVC microparticles over a 14-d period. The results showed that hepatic copper accumulation is facilitated by the PVC microparticles presence in water. All treatments induced significant hepatic stress and inflammation; however, the transcriptional responses involving in detoxification pathways and apoptotic mechanisms were mixed and often down-regulated in the fish exposed to copper and/or PVC microparticles. Exposure to copper and/or PVC microparticles induced hypermeia, leukocyte infiltration and increase in melanomacrophage centers number and area. Generally, the severity of the lesions was in the following order: PVC microparticles |
| doi_str_mv | 10.1016/j.marpolbul.2022.113401 |
| format | article |
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•Common carp were exposed to copper, pristine PVC microplastic (PVC-MP) and copper + PVC-MP.•Copper accumulation in common carp was facilitated by pristine PVC-MP.•Co-exposure of common carp to copper and MPVC resulted in the highest liver damage.•Copper exposure decreased transcription of detoxification- and apoptosis-related genes.</description><identifier>ISSN: 0025-326X</identifier><identifier>EISSN: 1879-3363</identifier><identifier>DOI: 10.1016/j.marpolbul.2022.113401</identifier><identifier>PMID: 35144215</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Accumulation ; Animals ; Apoptosis ; Bioaccumulation ; Biomarkers ; Carps - metabolism ; Co-exposure ; Copper ; Copper - pharmacology ; Cyprinus carpio ; Detoxification ; Exposure ; Fish ; Freshwater fishes ; Gene expression ; Gills - metabolism ; Heavy metals ; Hepatic damage ; Histopathology ; Lesions ; Leukocytes ; Liver ; Liver - metabolism ; Microparticles ; Microplastics ; Plastics - metabolism ; Polyvinyl chloride ; PVC microparticle ; Transcription ; Transcriptome ; Transcriptomics ; Water Pollutants, Chemical - metabolism</subject><ispartof>Marine pollution bulletin, 2022-02, Vol.175, p.113401-113401, Article 113401</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Feb 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-acfefcb4dbafde3819b5b927dd56472315befb916a35f2b3a92ff53328a71ac83</citedby><cites>FETCH-LOGICAL-c448t-acfefcb4dbafde3819b5b927dd56472315befb916a35f2b3a92ff53328a71ac83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35144215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoseini, Seyyed Morteza</creatorcontrib><creatorcontrib>Khosraviani, Kave</creatorcontrib><creatorcontrib>Hosseinpour Delavar, Fatemeh</creatorcontrib><creatorcontrib>Arghideh, Mohammad</creatorcontrib><creatorcontrib>Zavvar, Fatemeh</creatorcontrib><creatorcontrib>Hoseinifar, Seyed Hossein</creatorcontrib><creatorcontrib>Van Doan, Hien</creatorcontrib><creatorcontrib>Zabihi, Erfan</creatorcontrib><creatorcontrib>Reverter, Miriam</creatorcontrib><title>Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure</title><title>Marine pollution bulletin</title><addtitle>Mar Pollut Bull</addtitle><description>The combined effects of copper and polyvinyl chloride (PVC) microparticles were investigated on the metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The fish were exposed to 0.25 mg/L copper and/or 0.5 mg/L PVC microparticles over a 14-d period. The results showed that hepatic copper accumulation is facilitated by the PVC microparticles presence in water. All treatments induced significant hepatic stress and inflammation; however, the transcriptional responses involving in detoxification pathways and apoptotic mechanisms were mixed and often down-regulated in the fish exposed to copper and/or PVC microparticles. Exposure to copper and/or PVC microparticles induced hypermeia, leukocyte infiltration and increase in melanomacrophage centers number and area. Generally, the severity of the lesions was in the following order: PVC microparticles < copper < copper+ PVC microparticles. In conclusion, PVC MPs act as a copper vector, facilitating accumulation of copper in the fish liver and increasing the tissue damage.
•Common carp were exposed to copper, pristine PVC microplastic (PVC-MP) and copper + PVC-MP.•Copper accumulation in common carp was facilitated by pristine PVC-MP.•Co-exposure of common carp to copper and MPVC resulted in the highest liver damage.•Copper exposure decreased transcription of detoxification- and apoptosis-related genes.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Bioaccumulation</subject><subject>Biomarkers</subject><subject>Carps - metabolism</subject><subject>Co-exposure</subject><subject>Copper</subject><subject>Copper - pharmacology</subject><subject>Cyprinus carpio</subject><subject>Detoxification</subject><subject>Exposure</subject><subject>Fish</subject><subject>Freshwater fishes</subject><subject>Gene expression</subject><subject>Gills - metabolism</subject><subject>Heavy metals</subject><subject>Hepatic damage</subject><subject>Histopathology</subject><subject>Lesions</subject><subject>Leukocytes</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Microparticles</subject><subject>Microplastics</subject><subject>Plastics - metabolism</subject><subject>Polyvinyl chloride</subject><subject>PVC microparticle</subject><subject>Transcription</subject><subject>Transcriptome</subject><subject>Transcriptomics</subject><subject>Water Pollutants, Chemical - metabolism</subject><issn>0025-326X</issn><issn>1879-3363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi1ERbeFvwCRuHBoFn_ETnKsVkCRKvUCEjfLdsbUqyQ2nqSi6p_H2y09cOFkjfzM6xk_hLxjdMsoUx_328nkFEe7jltOOd8yJhrKXpAN69q-FkKJl2RDKZe14OrHKTlD3FNKW96yV-RUSNY0nMkNebiCZJbgqiWbGV0OaYlTKc08VLcBl1hub-MYfwZnxioDpjgjYBV95eI0xblyZZCLanefcphXfCxDvKiWWICUID9Glcgc02jw8BT8ThHXDK_JiTcjwpun85x8__zp2-6qvr758nV3eV27pumW2jgP3tlmsMYPIDrWW2l73g6DVE3LBZMWvO2ZMkJ6boXpufdSCN6ZlhnXiXPy4Zibcvy1Ai56CuhgHM0McUXNFe94L1XHCvr-H3Qf1zyX6QrVdFwJxQ6B7ZEqSyFm8LosX4Tca0b1wY_e62c_-uBHH_2UzrdP-audYHju-yukAJdHAMqH3AXIGl2A2cEQMrhFDzH895E_bhqo3w</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Hoseini, Seyyed Morteza</creator><creator>Khosraviani, Kave</creator><creator>Hosseinpour Delavar, Fatemeh</creator><creator>Arghideh, Mohammad</creator><creator>Zavvar, Fatemeh</creator><creator>Hoseinifar, Seyed Hossein</creator><creator>Van Doan, Hien</creator><creator>Zabihi, Erfan</creator><creator>Reverter, Miriam</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T7</scope><scope>7TN</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>202202</creationdate><title>Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure</title><author>Hoseini, Seyyed Morteza ; Khosraviani, Kave ; Hosseinpour Delavar, Fatemeh ; Arghideh, Mohammad ; Zavvar, Fatemeh ; Hoseinifar, Seyed Hossein ; Van Doan, Hien ; Zabihi, Erfan ; Reverter, Miriam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-acfefcb4dbafde3819b5b927dd56472315befb916a35f2b3a92ff53328a71ac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Accumulation</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Bioaccumulation</topic><topic>Biomarkers</topic><topic>Carps - metabolism</topic><topic>Co-exposure</topic><topic>Copper</topic><topic>Copper - pharmacology</topic><topic>Cyprinus carpio</topic><topic>Detoxification</topic><topic>Exposure</topic><topic>Fish</topic><topic>Freshwater fishes</topic><topic>Gene expression</topic><topic>Gills - metabolism</topic><topic>Heavy metals</topic><topic>Hepatic damage</topic><topic>Histopathology</topic><topic>Lesions</topic><topic>Leukocytes</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Microparticles</topic><topic>Microplastics</topic><topic>Plastics - metabolism</topic><topic>Polyvinyl chloride</topic><topic>PVC microparticle</topic><topic>Transcription</topic><topic>Transcriptome</topic><topic>Transcriptomics</topic><topic>Water Pollutants, Chemical - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoseini, Seyyed Morteza</creatorcontrib><creatorcontrib>Khosraviani, Kave</creatorcontrib><creatorcontrib>Hosseinpour Delavar, Fatemeh</creatorcontrib><creatorcontrib>Arghideh, Mohammad</creatorcontrib><creatorcontrib>Zavvar, Fatemeh</creatorcontrib><creatorcontrib>Hoseinifar, Seyed Hossein</creatorcontrib><creatorcontrib>Van Doan, Hien</creatorcontrib><creatorcontrib>Zabihi, Erfan</creatorcontrib><creatorcontrib>Reverter, Miriam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Marine pollution bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoseini, Seyyed Morteza</au><au>Khosraviani, Kave</au><au>Hosseinpour Delavar, Fatemeh</au><au>Arghideh, Mohammad</au><au>Zavvar, Fatemeh</au><au>Hoseinifar, Seyed Hossein</au><au>Van Doan, Hien</au><au>Zabihi, Erfan</au><au>Reverter, Miriam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure</atitle><jtitle>Marine pollution bulletin</jtitle><addtitle>Mar Pollut Bull</addtitle><date>2022-02</date><risdate>2022</risdate><volume>175</volume><spage>113401</spage><epage>113401</epage><pages>113401-113401</pages><artnum>113401</artnum><issn>0025-326X</issn><eissn>1879-3363</eissn><abstract>The combined effects of copper and polyvinyl chloride (PVC) microparticles were investigated on the metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The fish were exposed to 0.25 mg/L copper and/or 0.5 mg/L PVC microparticles over a 14-d period. The results showed that hepatic copper accumulation is facilitated by the PVC microparticles presence in water. All treatments induced significant hepatic stress and inflammation; however, the transcriptional responses involving in detoxification pathways and apoptotic mechanisms were mixed and often down-regulated in the fish exposed to copper and/or PVC microparticles. Exposure to copper and/or PVC microparticles induced hypermeia, leukocyte infiltration and increase in melanomacrophage centers number and area. Generally, the severity of the lesions was in the following order: PVC microparticles < copper < copper+ PVC microparticles. In conclusion, PVC MPs act as a copper vector, facilitating accumulation of copper in the fish liver and increasing the tissue damage.
•Common carp were exposed to copper, pristine PVC microplastic (PVC-MP) and copper + PVC-MP.•Copper accumulation in common carp was facilitated by pristine PVC-MP.•Co-exposure of common carp to copper and MPVC resulted in the highest liver damage.•Copper exposure decreased transcription of detoxification- and apoptosis-related genes.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35144215</pmid><doi>10.1016/j.marpolbul.2022.113401</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0025-326X |
| ispartof | Marine pollution bulletin, 2022-02, Vol.175, p.113401-113401, Article 113401 |
| issn | 0025-326X 1879-3363 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Accumulation Animals Apoptosis Bioaccumulation Biomarkers Carps - metabolism Co-exposure Copper Copper - pharmacology Cyprinus carpio Detoxification Exposure Fish Freshwater fishes Gene expression Gills - metabolism Heavy metals Hepatic damage Histopathology Lesions Leukocytes Liver Liver - metabolism Microparticles Microplastics Plastics - metabolism Polyvinyl chloride PVC microparticle Transcription Transcriptome Transcriptomics Water Pollutants, Chemical - metabolism |
| title | Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure |
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