Synthesis of a Lanthanide Metal–Organic Framework and Its Fluorescent Detection for Phosphate Group-Based Molecules Such as Adenosine Triphosphate

• Published in: Inorganic chemistry 2022-02, Vol.61 (7), p.3132-3140
• Main Authors: Zhao, Peiran, Liu, Yuqian, He, Cheng, Duan, Chunying
• Format: Article
• Language: English
• Subjects: Adenosine Triphosphate - analysis; Adenosine Triphosphate - chemistry; Europium - chemistry; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Lanthanoid Series Elements - chemistry; Metal-Organic Frameworks - chemical synthesis; Metal-Organic Frameworks - chemistry; Molecular Structure; Spectrometry, Fluorescence
• ISSN: 0020-1669; 1520-510X; 1520-510X
• DOI: 10.1021/acs.inorgchem.1c03412

Adenosine triphosphate (ATP) is an important kind of metabolized biological molecule that is formed in organisms, especially in mitochondria, is used universally as energy, and is one of the most significant multifunctional biological molecules. Metal–organic frameworks (MOFs) have been widely used in many applications such as gas storage and separation, drug delivery, heterogeneous catalysis, chemical sensors, etc. Remarkably, lanthanide MOFs (Ln-MOFs), which display large pores, multiple dimensions, and unique lanthanide luminescence properties, are widely used as chemical sensors. A novel three-dimensional probe, Eu2(sbdc)3(H2O)3 (Eu-sbdc), was successfully self-assembled with Eu­(NO3)3·6H2O and 5,5-dioxo-5H-dibenzo­[b,d]­thiophene-3,7-dicarboxylic acid (H2sbdc). The Ln-MOF Eu-sbdc can quickly and effectively optically detect ATP via a luminescent quenching mechanism. The K sv value of Eu-sbdc is 1.02 × 104 M–1, and the lower detection limit of Eu-sbdc for ATP is 20 μM, which is more sensitive to ATP. Its mechanism of monitoring ATP might be a dynamic or static quenching process. Eu-sbdc could effectively and quickly recognize ATP with high sensitivity.