In Vitro Assessment of Sunscreen Efficacy Using Fourier Transform Infrared (FTIR) Spectroscopy on Synthetic Skin

Although there are several methods for assessing the sun protection factor (SPF) of sunscreen products, there is no standard and reliable in vitro method. Each test entails limitations and drawbacks. Therefore, this study aimed to assess the employability of FTIR as an alternative and quick method t...

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Bibliographic Details
Published in:AAPS PharmSciTech 2022-02, Vol.23 (2), p.73-73, Article 73
Main Authors: Al-Saeedi, Farah Mahdi Abd Ali, Dahmash, Eman Zmaily
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Fourier Analysis
Pharmacology/Toxicology
Pharmacy
Research Article
Skin
Skin, Artificial
Spectroscopy, Fourier Transform Infrared
Sunscreening Agents
Ultraviolet Rays
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Summary:Although there are several methods for assessing the sun protection factor (SPF) of sunscreen products, there is no standard and reliable in vitro method. Each test entails limitations and drawbacks. Therefore, this study aimed to assess the employability of FTIR as an alternative and quick method to evaluate the efficacy of various sunscreen formulations, their concentrations, and the timing of their application. Infrared radiation has longer wavelengths than ultraviolet, penetrates deeply into the skin, and hence enables the understanding of sunscreens’ ability to block the transmission of radiation. The FTIR transmission using synthetic skin to study the effect of sunscreen agents (oxybenzone, octyl methoxycinnamate, titanium dioxide (TiO 2 ), and zinc oxide (ZnO)) was conducted in the range 450–4000cm −1 . Comparison studies were made at the peak of 805cm −1 . After 2 h of sunscreen application, using the maximum concentrations, the FTIR peak at wavenumber 805cm −1 demonstrated a significant reduction of transmission from 96.55 to 60.09%, 57.59%, 32.02%, and 37.1% for oxybenzone, octyl methoxycinnamate, TiO 2 , and ZnO respectively ( P
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-022-02224-w