Long-term outcome of vagus nerve stimulation for drug-resistant epilepsy using continuous assessment, with a note on mortality

•Retrospective clinical audit of 171 patients from a routine NHS-VNS clinic.•Responder or non-responder patients largely identified after two years of treatment.•Responders were stable over periods up to 12 years.•Non-responders were more likely to suffer epilepsy deaths than responders. To examine...

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Bibliographic Details
Published in:Seizure (London, England) England), 2022-03, Vol.96, p.74-78
Main Authors: Polkey, Charles E, Nashef, Lina, Queally, Cathy, Selway, Richard, Valentin, Antonio
Format: Article
Language:English
Subjects:
Epilepsy
Epilepsy - therapy
Humans
Mortality
Outcome
Retrospective Studies
State Medicine
Stimulation
Treatment Outcome
Vagus Nerve
Vagus Nerve Stimulation
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Summary:•Retrospective clinical audit of 171 patients from a routine NHS-VNS clinic.•Responder or non-responder patients largely identified after two years of treatment.•Responders were stable over periods up to 12 years.•Non-responders were more likely to suffer epilepsy deaths than responders. To examine the outcome of vagus nerve stimulation (VNS) for drug-resistant epilepsy using data from a National Health Service VNS clinic. Clinical records of patients implanted with VNS for epilepsy between1995 and 2010 were examined. Patients were selected for study who had at least one year of therapeutic stimulation (minimum 1 mA stimulator current) and follow-up by our service with analysable electronic records, providing continuous assessment of seizure control during available follow-up. Seizure status at each attendance was assessed and graded 1–4 (1=seizure free or
ISSN:1059-1311
1532-2688
DOI:10.1016/j.seizure.2022.01.017