Desmoplastic reactions and epithelial-mesenchymal transition proteins in stages II and III colorectal cancer: association with and prognostic value for disease-free survival

Recent study has shown that there is a close association of desmoplastic reactions (DRs) with the survival of patient with colorectal cancer (CRC). Here, we examined the correlation of DR classification with disease-free survival and overall survival of CRC. Moreover, we also investigated the associ...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2022-04, Vol.480 (4), p.793-805
Main Authors: Hashimoto, Mai, Uesugi, Noriyuki, Sugai, Mayu, Ito, Kazuhiro, Yanagawa, Naoki, Otsuka, Koki, Kajiwara, Yoshiki, Ueno, Hideki, Sasaki, Akira, Sugai, Tamotsu
Format: Article
Language:English
Subjects:
Cancer
Classification
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Correlation
Disease-Free Survival
Epithelial-Mesenchymal Transition
Humans
Immunohistochemistry
Male
Markers
Medical prognosis
Medicine
Medicine & Public Health
Mesenchyme
Neoplasm Staging
Original Article
Pathology
Prognosis
Proteins
Survival
Testicular Neoplasms - pathology
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Summary:Recent study has shown that there is a close association of desmoplastic reactions (DRs) with the survival of patient with colorectal cancer (CRC). Here, we examined the correlation of DR classification with disease-free survival and overall survival of CRC. Moreover, we also investigated the association of the histological transition of the DR with the expression of cancer-associated fibroblast (CAF)- and epithelial-mesenchymal transition (EMT)-related proteins in CRC in stages II and III. We examined 157 cases of stage II CRC and 163 cases in stage III. We classified DRs into mature, intermediate, and immature types and examined the correlation of the DR patterns with patient survival. Next, the expression of CAF- and EMT-related markers was examined in CRC samples using immunohistochemistry. In stage II CRC, we found a significant correlation of disease-free survival with DR subtype (immature vs mature) in univariate and multivariate analyses. In stage III CRC, however, such association was not identified. Finally, the DR was closely associated with two EMT-related markers in stages II and III CRC. Our findings suggest that classification of the DR may help to predict patient prognosis in CRC. Furthermore, classification of the DR is correlated with the expression of EMT-related proteins.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-021-03266-4