Importance of a functional measure in the evaluation of patients in a memory clinic: Validation of the Serbian version of the Amsterdam instrumental activities of daily living questionnaire

• Published in: Clinical neurology and neurosurgery 2022-03, Vol.214, p.107165-107165, Article 107165
• Main Authors: Milosevic, Vuk Milošević, Malobabic Marina Malobabić, Stojanovic, Ivana Stojanović, Basic, Jelena Bašić
• Format: Article
• Language: English
• Subjects: Activities of daily living; Activities of Daily Living - psychology; Age; Alzheimer's disease; Between-subjects design; Cognition & reasoning; Cognitive ability; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - psychology; Dementia; Dementia - diagnosis; Dementia - psychology; Dementia disorders; Diagnosis; Education; Female; Gender; Humans; Instrumental activities of daily living; Interpreters; Language; Male; Memory; Neuroimaging; Neurology; Neuropsychological Tests; Questionnaire; Questionnaires; Reproducibility; Reproducibility of Results; Serbia; Statistical analysis; Surveys and Questionnaires; Tau protein; Translations; Validation; Validation studies; Validity; Variance analysis
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2022.107165

The Amsterdam instrumental activities of daily living questionnaire (A-IADL-Q) was developed as a sensitive tool in detecting a functional decline in early dementia. The aim of our study was to analyze the validity and reliability of the Serbian translation of the short version of A-IADL-Q in a population of memory clinic patients. We have included 160 subjects with Alzhemier's disease (AD) dementia, mild cognitive impairment (MCI), or normal cognition (NC). All patients were examined by a neurologist, screened for cognitive impairment (MMSE) and depression, and referred to laboratory testing, neuroimaging examination, and neuropsychological assessment. Informants (close friends or relatives) completed Serbian language versions of the A-IADL-Q –Short version and the Lawton-Brody Instrumental Activities of Daily Living (LB-IADL) scale. Reliability analysis was performed by assessing internal consistency and reproducibility (test-retest reliability). Construct validity was assessed as the impact of gender, аgе, education, diagnosis, cognitive and functional measures on A-IADL-Q scores. The internal consistency of the Serbian version of A-IADL-Q was acceptable (Cronbach's alpha 0.82), Test-retest reliability of the A-IADL-Q was excellent (ICC=0.92, 95% CI 0.84–0.98, p