Adhesive, Antibacterial, Conductive, Anti-UV, Self-Healing, and Tough Collagen-Based Hydrogels from a Pyrogallol-Ag Self-Catalysis System

Recently, versatile hydrogels with multifunctionality have been widely developed with emerging applications as wearable and implantable devices. In this work, we reported novel versatile hydrogels by self-catalyzing the gelation of an interpenetrating polymer network consisting of acrylic acid (AA)...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2022-02, Vol.14 (7), p.8728-8742
Main Authors: Zhang, Min, Yang, Qili, Hu, Tianshuo, Tang, Lele, Ni, Yonghao, Chen, Lihui, Wu, Hui, Huang, Liulian, Ding, Cuicui
Format: Article
Language:English
Subjects:
Adhesives
Animals
Anti-Bacterial Agents - pharmacology
Biological and Medical Applications of Materials and Interfaces
Catalysis
Collagen
Hydrogels - pharmacology
Metal Nanoparticles
Mice
Pyrogallol
Silver - pharmacology
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Summary:Recently, versatile hydrogels with multifunctionality have been widely developed with emerging applications as wearable and implantable devices. In this work, we reported novel versatile hydrogels by self-catalyzing the gelation of an interpenetrating polymer network consisting of acrylic acid (AA) monomers and GA-modified collagen (GCOL) in situ decorated silver nanoparticles (AgNPs). The resultant hydrogel, namely AgNP@GCOL/PAA, has many desirable features, including good mechanical properties (such as 123 kPa, 916%, and 1961 J m−2 for the fracture stress, strain and tearing energy) that match with those of animal skin, excellent self-healing performance, favorable conductivity and strain sensitivity as a flexible biosensor, and excellent antibacterial and anti-UV properties, as well as the strong adhesiveness on skin. Moreover, AgNP@GCOL/PAA showed excellent biocompatibility via in vitro cell culture. Remarkably, AgNP@GCOL/PAA displayed superior hemostatic properties with sharply decreasing blood loss for a mouse liver incision, closely related to its strong self-adhesion which produced anchoring strength to the bleeding site and thus formed a network barrier with liver tissue. This study provides new opportunities for the facile preparation of widely used multifunctional collagen-based hydrogels based on a simple pyrogallol-Ag system.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.1c21200