Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype

Pre-eclampsia complicates 4.6% of pregnancies and is linked to impaired placentation; likely due to dysregulated vasculogenesis/angiogenesis. Proteoglycans, such as biglycan, are located on the endothelial surface of fetal capillaries. Biglycan is reduced in the placenta of pregnancies complicated b...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2022-03, Vol.119, p.52-62
Main Authors: Briffa, J.F., Bevens, W., Gravina, S., Said, J.M., Wlodek, M.E.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Angiogenesis
Animals
Biglycan
Biglycan - physiology
Female
Male
Maternal cardiorenal health
Mice
Mice, Inbred C57BL
Mice, Knockout
Neovascularization, Physiologic
Placenta
Pre-Eclampsia - etiology
Pregnancy
Vascularization
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Summary:Pre-eclampsia complicates 4.6% of pregnancies and is linked to impaired placentation; likely due to dysregulated vasculogenesis/angiogenesis. Proteoglycans, such as biglycan, are located on the endothelial surface of fetal capillaries. Biglycan is reduced in the placenta of pregnancies complicated by fetal growth restriction and pre-eclampsia. Importantly, biglycan stimulates angiogenesis in numerous tissues. Therefore, this study investigated whether biglycan knockdown in mice results in a pre-eclamptic phenotype. Wild-type (WT) and Bgn-/- mice underwent cardiorenal measurements prior to and during pregnancy. One cohort of mice underwent post-mortem on gestational day 18 (E18) and another cohort underwent post-mortem on postnatal day 1 (PN1), with maternal and offspring tissues of relevance collected. Bgn-/- dams had increased heart rate (+9%, p 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2022.02.002