Current nano-therapeutic approaches ameliorating inflammation in cancer progression

• Published in: Seminars in cancer biology 2022-11, Vol.86, p.886-908
• Main Authors: Rehman, Muneeb U., Khan, Andleeb, Imtiyaz, Zuha, Ali, Shafat, Makeen, Hafiz Antar, Rashid, Summya, Arafah, Azher
• Format: Article
• Language: English
• Subjects: Cancer progression; Inflammation; Nanotechnology; Nanotoxicity
• ISSN: 1044-579X; 1096-3650
• DOI: 10.1016/j.semcancer.2022.02.006

Cancer is one of the biggest causes of mortality in the world. The advances in cancer research have taken us to distance in understanding the disease, which helps develop therapeutic strategies. Surgery and chemotherapy are the two main chosen routes of combat for cancer. These chemotherapeutic agents are good at targeting cancer, but many lack the specificity to make the distinction between healthy cells. Also, the toxicity of these chemotherapeutic agents is very high. This gap makes it quintessential to either look for better and safe agents or makes it possible for existing agents to meet these needs. Nanotechnology has the potential to deal with these unmet needs. Nanotechnology has been a hot topic recently due to its applications, one of these being nanomedicine. Studies have proven that cancer nanomedicine has a scope of being revolutionary. With the help of nanoparticles, we can make drugs specific for the cancer tissue; it can also help in increasing the bioavailability of the drug. A nanoparticle can be modified as such that it can carry the drug load that is required and deliver it to the specific target. In this review article, we have discussed the advances in nanomedicine and the current clinical status of various nanomedicines. We have extensively explored various strategies used to develop cancer nanomedicine while also discussing their mechanism of action.