Carboxymethyl cellulose-based hydrogel film combined with berberine as an innovative tool for chronic wound management

Polysaccharide-based hydrogels are achieving remarkable performances in chronic wounds treatment. In this work, a carboxymethyl cellulose-based hydrogel film was developed to support skin repair. The hydrogel was loaded with berberine, a polyphenolic molecule endowing antioxidant and cytoprotective...

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Bibliographic Details
Published in:Carbohydrate polymers 2022-05, Vol.283, p.119145-119145, Article 119145
Main Authors: Cometa, S., Licini, C., Bonifacio, M.A., Mastrorilli, P., Mattioli-Belmonte, M., De Giglio, E.
Format: Article
Language:English
Subjects:
Antioxidants - pharmacology
Bandages
Berberine
Berberine - chemistry
Berberine - pharmacology
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Carboxymethylcellulose Sodium - chemistry
Cell Survival - drug effects
Chronic wound
CMC-based film
Fibroblasts
Fibroblasts - drug effects
Humans
Hydrogels - chemistry
Hydrogels - pharmacology
Keratinocytes
Keratinocytes - drug effects
Oxidative Stress - drug effects
Spectroscopy, Fourier Transform Infrared - methods
Temperature
Topical delivery
Wound Healing - drug effects
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Summary:Polysaccharide-based hydrogels are achieving remarkable performances in chronic wounds treatment. In this work, a carboxymethyl cellulose-based hydrogel film was developed to support skin repair. The hydrogel was loaded with berberine, a polyphenolic molecule endowing antioxidant and cytoprotective features. The film was physico-chemically characterized and in vitro tested on keratinocytes and fibroblasts subjected to oxidative stress. The biocomposite showed high thermal stability (onset decomposition temperature 245 °C) and significant fluid uptake performances, both in free conditions (up to 6510%) and under external pressure (up to 3400%). Moreover, it was able to control oxidative stress and inflammation markers involved in wound chronicity. Keratinocytes hyperproliferation, features that normally hamper injury restoration, was reduced of 25%. Our results showed that the combination of berberine and hydrogel provides a synergic improvement of the material properties. The biocomposite represents a promising candidate for dermatological applications against oxidative stress at the chronic wound site, promoting the healing process. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2022.119145