Altered insulin, leptin and ghrelin hormone levels and atypical estrous cycle lengths in two highly fertile mouse lines

Mouse models of decreased fertility mainly support scientific knowledge in the field of reproductive biology. In this study, we changed the perspective, using Dummerstorf high‐fertility mouse lines FL1 and FL2 selected for increased reproductive performances that doubled the amount of ovulated oocyt...

Full description

Saved in:
Bibliographic Details
Published in:Reproduction in domestic animals 2022-06, Vol.57 (6), p.577-586
Main Authors: Calanni‐Pileri, Michela, Weitzel, Joachim M., Langhammer, Martina, Wytrwat, Erika, Michaelis, Marten
Format: Article
Language:English
Subjects:
Animal models
estrous cycle
Estrus cycle
Fertility
Gametocytes
Ghrelin
Glucagon
Gonadotropin-releasing hormone
high‐fertility
Insulin
Leptin
long‐term selection mouse lines
Offspring
Oocytes
Phenotypes
Plasma levels
Pregnancy
Reproductive cycle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mouse models of decreased fertility mainly support scientific knowledge in the field of reproductive biology. In this study, we changed the perspective, using Dummerstorf high‐fertility mouse lines FL1 and FL2 selected for increased reproductive performances that doubled the amount of ovulated oocytes per cycle and the number of offspring per litter compared to an unselected control line (founder population, FZTDU, ctrl). After recent observations, both fertility lines seem to show a lower pregnancy rate compared to ctrl together with an atypical reproductive cycle. We analysed the estrous cycle of those mice, but also plasma levels of insulin, glucagon, leptin and ghrelin that, when irregular, may have an impact on the reproductive cycle length by modifying the GnRH release. We included females of another independent line (DU6P), selected from the same founder population but independently of fertility traits, as an additional model of decreased pregnancy rate. We aim to evaluate if do they use a similar mechanism associated in the regulation of the estrous cycle or implicated in altered pregnancy mechanism compared to control, because they show a similar situation as FL2 line does, even without an increase in fertility parameters. We speculate that FLs’ estrous cycle undergoes changes during the selection period and aim to demonstrate that some hormonal dysfunctions link with altered reproductive cycle, dampened pregnancy rates and reduced first delivery rates mostly in FL2, but also with higher‐fertility phenotype rather than lower in both FLs.
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.14097