Stress-related dysautonomias and neurocardiology-based treatment approaches

Cardiovascular and psychiatric disorders are among the most commonly treated conditions worldwide. Research in neurocardiology, psychiatry, and epidemiology have defined bidirectional relationships between psychiatric disorders and heart disease, affirming the role of impaired autonomic nervous syst...

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Bibliographic Details
Published in:Autonomic neuroscience 2022-05, Vol.239, p.102944-102944, Article 102944
Main Authors: Gurel, Nil Z., Hadaya, Joseph, Ardell, Jeffrey L.
Format: Article
Language:English
Subjects:
Autonomic Nervous System
Bioelectronic medicine
Dorsal root ganglia
Dysautonomia
Heart
Heart Rate - physiology
Humans
Myocardial ischemia
Neurocardiology
Posttraumatic stress disorder
Primary Dysautonomias
Renal denervation
Spinal cord
Stress
tragus nerve stimulation
Transcranial magnetic stimulation
Vagus Nerve Stimulation
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Summary:Cardiovascular and psychiatric disorders are among the most commonly treated conditions worldwide. Research in neurocardiology, psychiatry, and epidemiology have defined bidirectional relationships between psychiatric disorders and heart disease, affirming the role of impaired autonomic nervous system, or dysautonomia in the prognosis and development in these disorders. These studies have fueled rapid clinical translation of experimental findings, with potential to complement existing pharmacological therapies. In this review, we comprehensively discuss the state-of-the-art investigations and novel treatment approaches for stress-related dysautonomias, emphasizing the effects of stress on the cardiac neuronal hierarchy. Increasing evidence suggests that autonomic modulation stands as an attractive therapeutic strategy in the treatment of dysautonomias that could complement existing therapies and possibly reduce the burden of drug-related side effects and treatment-resistant conditions. Further investigations regarding treatment optimization, selectivity, usability, and ethical concerns are required.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2022.102944