Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas

Abnormal expression of phosphatidylethanolamine-binding protein 4 (PEBP4) has been identified in various types of malignant tumors. In the present study, we investigated the expression of PEBP4 in meningioma cases and examined whether PEBP4 expression was correlated with outcomes among these patient...

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Published in:Clinical neurology and neurosurgery 2022-03, Vol.214, p.107148-107148, Article 107148
Main Authors: Huang, Ren-qiang, Chen, Feng, Jiang, Ying-bo, Jin, Yu-ming, Wang, Song-qing, Liang, Hai-hui, Chen, Zhi-peng, Qian, Jun
Format: Article
Language:English
Subjects:
Antibodies
Brain cancer
Clinical outcomes
Colorectal cancer
Humans
Immunoreactivity
Ki-67 Antigen - metabolism
Lung cancer
Medical prognosis
Meningeal Neoplasms - pathology
Meningioma
Meningioma - pathology
Metastasis
Neoplasm Recurrence, Local - pathology
Nervous system
Patients
Phosphatidylethanolamine
Phosphatidylethanolamine Binding Protein - metabolism
Phosphatidylethanolamine-binding protein 4
Prognosis
Proteins
Radiation therapy
Recurrence
Survival analysis
Tumors
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Summary:Abnormal expression of phosphatidylethanolamine-binding protein 4 (PEBP4) has been identified in various types of malignant tumors. In the present study, we investigated the expression of PEBP4 in meningioma cases and examined whether PEBP4 expression was correlated with outcomes among these patients. The expression levels of PEBP4 and Ki-67 in human meningioma tissues from 65 patients were evaluated by immunohistochemical staining. The correlation between PEBP4 immunoreactivity in meningioma samples and patients’ clinical outcomes was examined using the Kruskal–Wallis correlation test. The prognostic value of PEBP4 expression in meningiomas patients also was investigated. Immunohistochemical analysis revealed up-regulated PEBP4 expression in both atypical and anaplastic meningiomas compared with classical meningiomas (13.38 ± 4.19% vs. 3.64 ± 2.04%, P 
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2022.107148