Pyrroloquinoline Quinone Chemistry, Biology, and Biosynthesis

The widely distributed, essential redox factor pyrroloquinoline quinone (PQQ, methoxatin) ( ) was discovered in the mid-1960s. The breadth and depth of its biological effects are steadily being revealed, and understanding its biosynthesis at the genomic level is a continuing process. In this review,...

Full description

Saved in:
Bibliographic Details
Published in:Chemical research in toxicology 2022-03, Vol.35 (3), p.355-377
Main Authors: Cordell, Geoffrey A, Daley, Sharna-Kay
Format: Article
Language:English
Subjects:
Biology
Oxidation-Reduction
PQQ Cofactor - genetics
PQQ Cofactor - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The widely distributed, essential redox factor pyrroloquinoline quinone (PQQ, methoxatin) ( ) was discovered in the mid-1960s. The breadth and depth of its biological effects are steadily being revealed, and understanding its biosynthesis at the genomic level is a continuing process. In this review, aspects of the chemistry, biology, biosynthesis, and commercial production of at the gene level, and some applications, are presented from discovery through to mid-2021.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.1c00340