Association between insulin resistance and incidence of carotid atherosclerotic plaque: A cohort study

There is limited evidence on the association between insulin resistance (IR) and carotid plaque was reported in prospective study. We aimed to exploit the relationship between IR and carotid plaque in a prospective cohort study. The study was performed in a functional community cohort in urban Beiji...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2022-04, Vol.32 (4), p.981-993
Main Authors: Lu, Ya-Ke, Dong, Jing, Li, Yan-Ling, Liu, Yu-Hong, Hu, Li-Kun, Chu, Xi, Yan, Yu-Xiang
Format: Article
Language:English
Subjects:
Blood Glucose
Carotid Intima-Media Thickness
Carotid plaque
Cohort Studies
HOMA-IR
Humans
Incidence
Insulin Resistance
Plaque, Atherosclerotic
Prospective Studies
Risk Factors
Triglycerides
TyG index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is limited evidence on the association between insulin resistance (IR) and carotid plaque was reported in prospective study. We aimed to exploit the relationship between IR and carotid plaque in a prospective cohort study. The study was performed in a functional community cohort in urban Beijing. In 2015, a total of 7061 individuals without intima-media thickness (IMT) thickening and carotid artery plaque were recruited and followed up until 2019. Restricted cubic spline was conducted to exploit the dose–response relationship between carotid plaque and baseline HOMA-IR or TyG index as continuous variables. Logistic regression was used to analyze the associations between carotid plaque and HOMA-IR or TyG index. During the average 4 years follow-up, 589 subjects developed carotid plaque. Both HOMA-IR and TyG index showed significant linear dose–response relationship on carotid plaque (p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2022.01.011