The influence of PM2.5 exposure on kidney diseases

The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related to chronic kidney disease and membranous nephropathy Basic research has demon...

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Published in:Human & experimental toxicology 2022-01, Vol.41, p.9603271211069982-9603271211069982
Main Authors: Xu, Wenqi, Wang, Shaopeng, Jiang, Liping, Sun, Xiance, Wang, Ningning, Liu, Xiaofang, Yao, Xiaofeng, Qiu, Tianming, Zhang, Cong, Li, Jing, Deng, Haoyuan, Yang, Guang
Format: Article
Language:English
Subjects:
Air pollution
Angiotensin
Animal diseases
Apoptosis
Autophagy
Damage
DNA damage
Epidemiology
Kidney diseases
Kidneys
Membranous nephropathy
Nephropathy
Oxidative stress
Particulate matter
Public health
Renal function
Renin
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Summary:The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related to chronic kidney disease and membranous nephropathy Basic research has demonstrated that PM2.5 has an impact on the normal function of the kidneys through accumulation in the kidney, endothelial dysfunction, abnormal renin-angiotensin system, and immune complex deposition. Moreover, the mechanism of PM2.5 damage to the kidney involves inflammation, oxidative stress, apoptosis, DNA damage, and autophagy. In this review, we summarized the latest developments in the effects of PM2.5 on kidney disease in human and animal studies, so as to provide new ideas for the prevention and treatment of kidney disease.
ISSN:0960-3271
1477-0903
DOI:10.1177/09603271211069982