Clinical 1H MRS in childhood neurometabolic diseases—part 1: technique and age-related normal spectra

Despite its vigorous ability to detect and measure metabolic disturbances, 1 H MRS remains underutilized in clinical practice. MRS increases diagnostic yield and provides therapeutic measures. Because many inborn metabolic errors are now treatable, early diagnosis is crucial to prevent or curb perma...

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Published in:Neuroradiology 2022-06, Vol.64 (6), p.1101-1110
Main Authors: Whitehead, Matthew T., Lai, Lillian M., Blüml, Stefan
Format: Article
Language:English
Subjects:
Age
Brain
Brain injury
Childhood
Children
Errors
Head injuries
Imaging
Injury prevention
Medicine
Medicine & Public Health
Metabolism
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Radiology
Review
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description Despite its vigorous ability to detect and measure metabolic disturbances, 1 H MRS remains underutilized in clinical practice. MRS increases diagnostic yield and provides therapeutic measures. Because many inborn metabolic errors are now treatable, early diagnosis is crucial to prevent or curb permanent brain injury. Therefore, patients with known or suspected inborn metabolic errors stand to benefit from the addition of MRS. With education and practice, all neuroradiologists can perform and interpret MRS notwithstanding their training and prior experience. In this two-part review, we cover the requisite concepts for clinical MRS interpretation including technical considerations and normal brain spectral patterns based on age, location, and methodology.
doi_str_mv 10.1007/s00234-022-02917-w
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subjects Age
Brain
Brain injury
Childhood
Children
Errors
Head injuries
Imaging
Injury prevention
Medicine
Medicine & Public Health
Metabolism
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Radiology
Review
title Clinical 1H MRS in childhood neurometabolic diseases—part 1: technique and age-related normal spectra
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