α -Glucosidase inhibitory and α -amylase inhibitory activities of compounds isolated from Uvaria rufa Blume

A new -benzylated flavone, uvariaruflavone ( ), along with 13 known compounds ( - ) were isolated from the twig and leaf extracts of Blume. Their structures were established by extensive spectroscopic methods. Flavones ( - ) and cyclohexene ( ) were isolated from for the first time. Most of the isol...

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Bibliographic Details
Published in:Natural product research 2022-12, Vol.36 (23), p.1-6043
Main Authors: Teerapongpisan, Passakorn, Suthiphasilp, Virayu, Maneerat, Tharakorn, Charoensup, Rawiwan, Duangyod, Thidarat, Andersen, Raymond J, Laphookhieo, Surat
Format: Article
Language:English
Subjects:
Amylases
Flavones
Glucosidase
Plant extracts
α-Amylase
α-Glucosidase
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Summary:A new -benzylated flavone, uvariaruflavone ( ), along with 13 known compounds ( - ) were isolated from the twig and leaf extracts of Blume. Their structures were established by extensive spectroscopic methods. Flavones ( - ) and cyclohexene ( ) were isolated from for the first time. Most of the isolated compounds were evaluated for their -glucosidase and -amylase inhibitory activities. Of these, uvariaruflavone ( ) showed the highest -glucosidase inhibitory activity with an IC value of 44.3 µM, while ferrudiol ( ) displayed the highest -amylase inhibitory activity with an IC value of 73.5 µM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2041010