Thiols and disulfide levels are correlated with TIMI thrombus grade in non-ST elevation myocardial infarction patients

We investigated the relationship between thrombolysis in myocardial infarction (TIMI) thrombus grade and thiol/disulfide levels. 182 non-ST elevation myocardial infarction (NSTEMI) patients were divided into two groups; TIMI grade 0 patients who do not have any visible thrombus in their culprit vess...

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Bibliographic Details
Published in:Biomarkers in medicine 2022-03, Vol.16 (4), p.233-240
Main Authors: Özbiçer, Süleyman, Yüksel, Gülhan, Urgun, Örsan D, Neşelioğlu, Salim, Erel, Özcan
Format: Article
Language:English
Subjects:
Coronary Angiography
disulfide
Disulfides
Humans
Myocardial Infarction
Non-ST Elevated Myocardial Infarction
non-ST elevation myocardial infarction
oxidative stress
Percutaneous Coronary Intervention
ST Elevation Myocardial Infarction
Sulfhydryl Compounds
thiols
Thrombosis
thrombus
Treatment Outcome
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Summary:We investigated the relationship between thrombolysis in myocardial infarction (TIMI) thrombus grade and thiol/disulfide levels. 182 non-ST elevation myocardial infarction (NSTEMI) patients were divided into two groups; TIMI grade 0 patients who do not have any visible thrombus in their culprit vessels, and TIMI thrombus grade 1–5 patients. Native and total thiol levels and disulfide to thiol ratio were higher in the low thrombus group. In addition, thrombus grade was positively correlated with disulfide to native and total thiol ratio and negatively with native and total thiol levels in NSTEMI patients. We can assert that thiol levels tend to decrease and the disulfide to thiol ratio increase, with the increasing thrombus burden in NSTEMI patients.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2021-0659