Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia

To evaluate the impact of quetiapine treatment on central set point of thyroid homeostasis in patients with acute phase schizophrenia. During Jan. 2016 to Dec. 2018, we conducted a retrospective cohort study in “the Second Affiliated Hospital of Xinxiang Medical University”. All patients admitted fo...

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Published in:Schizophrenia research 2022-03, Vol.241, p.244-250
Main Authors: Zhao, Ying, Guan, Qiongge, Shi, Jingyi, Sun, Jiewei, Wang, Qi, Yang, Jianzhou, Retnakaran, Ravi, Han, Jinhong, Zhang, Xiangyang, Hao, Wei, Huang, Xin, Zhang, Ruiling, Zhai, Desheng, Wen, Shi Wu
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Central set point
Quetiapine
Schizophrenia
Thyroid homeostasis
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container_title Schizophrenia research
container_volume 241
creator Zhao, Ying
Guan, Qiongge
Shi, Jingyi
Sun, Jiewei
Wang, Qi
Yang, Jianzhou
Retnakaran, Ravi
Han, Jinhong
Zhang, Xiangyang
Hao, Wei
Huang, Xin
Zhang, Ruiling
Zhai, Desheng
Wen, Shi Wu
description To evaluate the impact of quetiapine treatment on central set point of thyroid homeostasis in patients with acute phase schizophrenia. During Jan. 2016 to Dec. 2018, we conducted a retrospective cohort study in “the Second Affiliated Hospital of Xinxiang Medical University”. All patients admitted for treatment of schizophrenia being euthyroid at admission and reevaluated for thyroid function during hospitalization were recruited and followed until discharge. Patients treated with mood stabilizers during hospitalization were excluded. Quetiapine use was the exposure measure. The primary outcomes were the parameters of central set point of thyroid homeostasis measured by “thyroid-stimulating hormone (TSH) index” and “thyroid feedback quantile-based index (TFQI)”. Multiple regression models were used to estimate the association between quetiapine exposure and outcomes. A total of 1302 patients were enrolled in this study. Quetiapine exposure was associated with a more significant decline in the TSH index and TFQI, and the adjusted β and 95% confidence interval (CI) were −0.12 (−0.22, −0.01) and −0.10 (−0.15, −0.05), respectively. A dose-response association between quetiapine exposure and decline in TSH index and TFQI was observed (P 
doi_str_mv 10.1016/j.schres.2022.02.010
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During Jan. 2016 to Dec. 2018, we conducted a retrospective cohort study in “the Second Affiliated Hospital of Xinxiang Medical University”. All patients admitted for treatment of schizophrenia being euthyroid at admission and reevaluated for thyroid function during hospitalization were recruited and followed until discharge. Patients treated with mood stabilizers during hospitalization were excluded. Quetiapine use was the exposure measure. The primary outcomes were the parameters of central set point of thyroid homeostasis measured by “thyroid-stimulating hormone (TSH) index” and “thyroid feedback quantile-based index (TFQI)”. Multiple regression models were used to estimate the association between quetiapine exposure and outcomes. A total of 1302 patients were enrolled in this study. Quetiapine exposure was associated with a more significant decline in the TSH index and TFQI, and the adjusted β and 95% confidence interval (CI) were −0.12 (−0.22, −0.01) and −0.10 (−0.15, −0.05), respectively. A dose-response association between quetiapine exposure and decline in TSH index and TFQI was observed (P &lt; 0.05). Sensitivity analyses restricting to patients under mono-atypical antipsychotic therapy, or selecting patients in the non-quetiapine group matched to quetiapine group yielded similar results. 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subjects Central set point
Quetiapine
Schizophrenia
Thyroid homeostasis
title Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia
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