Gastrointestinal Symptoms in Type 1 Diabetes: Relationship With Autoimmune and Microvascular Complications

To assess reported rates of gastrointestinal (GI) symptoms and their association with autoimmune diseases and microvascular complications in adults and children with type 1 diabetes. The Gastrointestinal Symptom Scale was used to assess GI symptom type and severity in 2370 patients with type 1 diabe...

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Published in:The journal of clinical endocrinology and metabolism 2022-05, Vol.107 (6), p.e2431-e2437
Main Authors: De Melo, Emilia N, Clarke, Antoine B M, McDonald, Charlotte, Saibil, Fred, Lochnan, Heather A, Punthakee, Zubin, Assor, Esther, Marcon, Margaret A, Mahmud, Farid H
Format: Article
Language:English
Subjects:
Abdominal Pain - epidemiology
Abdominal Pain - etiology
Adult
Celiac Disease - complications
Celiac Disease - epidemiology
Child
Children
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - epidemiology
Glycated Hemoglobin A - analysis
Glycosylated hemoglobin
Health aspects
Humans
Kidney diseases
Odds Ratio
Pediatrics
Type 2 diabetes
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Summary:To assess reported rates of gastrointestinal (GI) symptoms and their association with autoimmune diseases and microvascular complications in adults and children with type 1 diabetes. The Gastrointestinal Symptom Scale was used to assess GI symptom type and severity in 2370 patients with type 1 diabetes aged 8 to 45 years evaluated as part of a clinical trial screening for celiac disease (CD). The presence and severity of GI symptoms and relationships with demographic, clinical, and other diabetes-related factors were evaluated. Overall, 1368 adults (57.7%) aged 19 to 45 years and 1002 (42.3%) pediatric patients aged 8 to 18 years were studied. At least 1 GI symptom was reported in 34.1% of adults as compared with 21.7% of children (P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgac093