Could blood groups have prognostic significance on survival in patients with diffuse large B cell lymphoma?

• Published in: Leukemia research 2022-04, Vol.115, p.106810-106810, Article 106810
• Main Authors: Ulu, Bahar Uncu, Başcı, Semih, Bakırtaş, Mehmet, Yiğenoğlu, Tuğçe Nur, Batgi, Hikmetullah, Yıldız, Jale, Darçın, Tahir, Şahin, Derya, Baysal, Nuran Ahu, İskender, Dicle, Çakar, Merih Kızıl, Dal, Mehmet Sinan, Altuntaş, Fevzi
• Format: Article
• Language: English
• Subjects: ABO blood groups; ABO Blood-Group System - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Diffuse large B-cell lymphoma; DLBCL; Humans; Lymphoma, Large B-Cell, Diffuse; Multivariate Analysis; Prognosis; Retrospective Studies; Rituximab - therapeutic use; Survival
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2022.106810

The prognostic importance of the ABO blood group in non-Hodgkin lymphoma is largely unknown. We aim to investigate the prognostic significance of blood groups on the survival in diffuse large B-cell lymphoma (DLBCL) patients. 412 people (206 DLBCL patients and 206 healthy donors) were included. The blood group types of patients treated at our center from 2009 to 2019 were analyzed retrospectively and compared to the results from healthy thrombocyte donors. The distribution of the ABO blood groups was as follows: blood type A (45.2%), B (9.7%), O (38.8%), and AB (6.3%). We found no statistically significant difference between patients and the control group in terms of ABO and Rhesus blood group distribution (p = 0.27 and p = 0.45, respectively). The median follow-up time was 18 months (0–116). In the Cox regression analysis ABO blood groups, and Rh group were not significant predictors of survival in patients with DLBCL, whereas ECOG score, IPI score, Ann-Arbor stage, and LDH level were found significant. Receiving R-CHOP as the first-line treatment was associated with better survival in the multivariate analysis. No statistically significant difference was found between the control and DLBCL patient groups regarding the distribution of ABO and Rh blood groups. •The prognostic importance of the ABO blood group in non-Hodgkin lymphoma is largely unknown.•ABO or Rh blood groups were not predictors of overall survival in DLBCL patients.