Novel Therapies for Critical Limb-Threatening Ischemia

Purpose of Review This review intends to discuss the latest endovascular and surgical advancement in the treatment of critical limb-threatening ischemia (CLTI). Recent Findings We discuss novel endovascular technological advancements such as intravascular lithotripsy, the Tack endovascular stent, th...

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Bibliographic Details
Published in:Current cardiology reports 2022-05, Vol.24 (5), p.513-517
Main Authors: Karimi, Ashkan, Lauria, Alexis L., Aryavand, Behdad, Neville, Richard F.
Format: Article
Language:English
Subjects:
Amputation
Cardiology
Chronic Disease
Chronic Limb-Threatening Ischemia
Endovascular Procedures - methods
Humans
Ischemia - surgery
Limb Salvage
Medicine
Medicine & Public Health
New Therapies for Cardiovascular Disease (AA Bavry and MR Massoomi
Peripheral Arterial Disease - surgery
Risk Factors
Section Editors
Time Factors
Topical Collection on New Therapies for Cardiovascular Disease
Treatment Outcome
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Summary:Purpose of Review This review intends to discuss the latest endovascular and surgical advancement in the treatment of critical limb-threatening ischemia (CLTI). Recent Findings We discuss novel endovascular technological advancements such as intravascular lithotripsy, the Tack endovascular stent, the PQ Bypass DETOUR system, and the LimFlow System for deep venous arterialization (DVA) in the very high risk “no-option” CLTI population. We also discuss the increasing adoption of radial and pedal approaches for endovascular revascularization and the tibiopedal arterial minimally invasive (TAMI) technique. On the surgical front, we discuss the distal vein patch technique and surgical and hybrid DVA. Summary Recent advancements in the treatment options of CLTI will likely lead to reducing the rate of major amputations if they are adopted in a collaborative environment in order to apply the most appropriate treatment option to each individual patient based on the anatomy, comorbidities, functional status, and local expertise.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-022-01669-6