Diagnostic performance and inter-observer variability to differentiate between T1- and T2-stage gallbladder cancers using multi-detector row CT

Purpose To evaluate the diagnostic performance and inter-observer variability of differentiating T1 and T2 gallbladder (GB) cancers using multi-detector row CT (MDCT). Methods This retrospective study included 151 patients with surgically confirmed T1 ( n  = 49)- or T2 ( n  = 102)-stage GB cancer wh...

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Published in:Abdominal imaging 2022-04, Vol.47 (4), p.1341-1350
Main Authors: Kwon, Yong Jae, Song, Kyoung Doo, Ko, Seong Eun, Hwang, Jeong Ah, Kim, Minji
Format: Article
Language:English
Subjects:
Accuracy
Cancer
Confidence intervals
Diagnostic systems
Gallbladder
Gallbladder cancer
Gallbladder Neoplasms - diagnostic imaging
Gastroenterology
Hepatobiliary
Hepatology
Humans
Imaging
Mathematical analysis
Medical diagnosis
Medicine
Medicine & Public Health
Observer Variation
Performance evaluation
Radiology
Retrospective Studies
ROC Curve
Sensitivity analysis
Sensitivity and Specificity
Statistical analysis
Thickening
Tomography, X-Ray Computed
Variability
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Summary:Purpose To evaluate the diagnostic performance and inter-observer variability of differentiating T1 and T2 gallbladder (GB) cancers using multi-detector row CT (MDCT). Methods This retrospective study included 151 patients with surgically confirmed T1 ( n  = 49)- or T2 ( n  = 102)-stage GB cancer who underwent contrast-enhanced MDCT from 2016 to 2020. Five radiologists (two experienced and three less experienced) evaluated the T-stage with a confidence level calculated using a six-point scale. GB cancers were morphologically classified into three types: polypoid, polypoid with wall thickening, and wall thickening. The diagnostic performance of T-staging was assessed using receiver operating characteristic (ROC) curve analysis. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated based on a binary scale (T1 = positive). Inter-observer agreement was assessed using Fleiss κ statistics. Results The area under the receiver operating characteristic (ROC) curve of each reviewer for T-staging ranged from 0.69 to 0.80 (median 0.77). The overall accuracy of the five radiologists was 78% (95% confidence interval [CI] 71–84%). Sensitivity was higher and specificity was lower in experienced radiologists than in less experienced radiologists ( P  
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-022-03450-3