Eosinophilic meningoencephalitis caused by rat lungworm (Angiostrongylus cantonensis) migration in a white-eared opossum (Didelphis albiventris) with concurrent distemper virus in southern Brazil

Angiostrongylus cantonensis is a worldwide zoonotic parasite that causes eosinophilic meningoencephalitis in many species of animals including humans. This report describes neuro-angiostrongylosis in a white-eared opossum that showed nervous clinical signs such as circling and depression. At necrops...

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Bibliographic Details
Published in:Parasitology research (1987) 2022-05, Vol.121 (5), p.1545-1549
Main Authors: Vielmo, Andréia, Schwertz, Claiton Ismael, Piva, Manoela Marchezan, Echenique, Joanna Vargas Zillig, De Lorenzo, Cíntia, Surita, Lívia Eichenberg, de Andrade, Caroline Pinto, Sonne, Luciana
Format: Article
Language:English
Subjects:
Angiostrongylus cantonensis
Animals
Biomedical and Life Sciences
Biomedicine
Brazil
Canine distemper
Concurrent infection
Didelphis
Distemper - complications
DNA Viruses
Dogs
Immunohistochemistry
Immunology
Inclusion bodies
Infectious Encephalitis
Leukocyte migration
Leukocytes (eosinophilic)
Medical Microbiology
Meningoencephalitis
Meningoencephalitis - diagnosis
Meningoencephalitis - veterinary
Microbiology
Necropsy
Parasitism
Parietal cells
Protozoology - Short Communication
Rats
Strongylida Infections - diagnosis
Strongylida Infections - veterinary
Viruses
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Description
Summary:Angiostrongylus cantonensis is a worldwide zoonotic parasite that causes eosinophilic meningoencephalitis in many species of animals including humans. This report describes neuro-angiostrongylosis in a white-eared opossum that showed nervous clinical signs such as circling and depression. At necropsy, no relevant macroscopic lesions were observed. Histologically, eosinophilic meningoencephalitis was associated with multiple sections of nematodes and many intracytoplasmic eosinophilic inclusion bodies within gastric parietal cells. Immunohistochemistry was strongly positive for canine distemper virus in the stomach but there was no immunolabeling in the brain. This study describes a fatal case of eosinophilic meningoencephalitis by A. cantonensis with canine distemper virus concurrent infection in a white-eared opossum in southern Brazil, with histological characterization and molecular confirmation of the parasitism.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-022-07471-1