High frame rate multi-perspective cardiac ultrasound imaging using phased array probes

• Published in: Ultrasonics 2022-07, Vol.123, p.106701-106701, Article 106701
• Main Authors: Liu, Peilu, de Hoop, Hein, Schwab, Hans-Martin, Lopata, Richard G.P.
• Format: Article
• Language: English
• Subjects: Algorithms; Animals; Echocardiography; Heart - diagnostic imaging; High frame rate; Image enhancement; Image fusion; Image registration; Multi-perspective; Phantoms, Imaging; Speckle statistics; Swine; Ultrasonography; Ultrasound
• ISSN: 0041-624X; 1874-9968
• DOI: 10.1016/j.ultras.2022.106701

•Developed an interleaved multi-probe ultrafast cardiac ultrasound imaging method.•Demonstrated and tested under a realistic ex-vivo beating porcine heart setup.•An image registration and two image fusion algorithms were developed.•Multi-probe images showed enlarged field-of-view and improved image contrast.•Improved and more isotropic resolution for the multi-probe images. Ultrasound (US) imaging is used to assess cardiac disease by assessing the geometry and function of the heart utilizing its high spatial and temporal resolution. However, because of physical constraints, drawbacks of US include limited field-of-view, refraction, resolution and contrast anisotropy. These issues cannot be resolved when using a single probe. Here, an interleaved multi-perspective 2-D US imaging system was introduced, aiming at improved imaging of the left ventricle (LV) of the heart by acquiring US data from two separate phased array probes simultaneously at a high frame rate. In an ex-vivo experiment of a beating porcine heart, parasternal long-axis and apical views of the left ventricle were acquired using two phased array probes. Interleaved multi-probe US data were acquired at a frame rate of 170 frames per second (FPS) using diverging wave imaging under 11 angles. Image registration and fusion algorithms were developed to align and fuse the US images from two different probes. First- and second-order speckle statistics were computed to characterize the resulting probability distribution function and point spread function of the multi-probe image data. First-order speckle analysis showed less overlap of the histograms (reduction of 34.4%) and higher contrast-to-noise ratio (CNR, increase of 27.3%) between endocardium and myocardium in the fused images. Autocorrelation results showed an improved and more isotropic resolution for the multi-perspective images (single-perspective: 0.59 mm × 0.21 mm, multi-perspective: 0.35 mm × 0.18 mm). Moreover, mean gradient (MG) (increase of 74.4%) and entropy (increase of 23.1%) results indicated that image details of the myocardial tissue can be better observed after fusion. To conclude, interleaved multi-perspective high frame rate US imaging was developed and demonstrated in an ex-vivo experimental setup, revealing enlarged field-of-view, and improved image contrast and resolution of cardiac images.