Mercuric chloride‐induced oxidative stress, genotoxicity, haematological changes and histopathological alterations in fish Channa punctatus (Bloch, 1793)

The present study was undertaken to investigate the adverse effects of mercuric chloride (HgCl2) overload in the fish Channa punctatus. Two sublethal test concentrations of HgCl2 (1/20th and 1/10th of 96 h LC50 i.e., 0.03 mg l−1 (low concentration) and 0.07 mg l−1 (high concentration), respectively,...

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Bibliographic Details
Published in:Journal of fish biology 2022-04, Vol.100 (4), p.868-883
Main Authors: Trivedi, Sunil P., Singh, Shefalee, Trivedi, Abha, Kumar, Manoj
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Biological stress
Catalase
Channa punctata
Chlorides
DNA Damage
Enzymatic activity
Enzyme activity
Erythrocytes
Exposure
Fish
Fishes - genetics
Genotoxicity
Glutathione
Glutathione - genetics
Glutathione - metabolism
Glutathione - pharmacology
Glutathione reductase
haematological changes
Hematology
histopathological alterations
Histopathology
Kidneys
Lipid Peroxidation
Liver
Malformations
Manganese
Mercuric chloride
Mercuric Chloride - toxicity
mercury chloride
Mercury compounds
Micronuclei
Mortality causes
Oxidative stress
Oxidative Stress - genetics
Reductases
Superoxide dismutase
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Superoxide Dismutase - pharmacology
Tissue
Toxicity tests
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Summary:The present study was undertaken to investigate the adverse effects of mercuric chloride (HgCl2) overload in the fish Channa punctatus. Two sublethal test concentrations of HgCl2 (1/20th and 1/10th of 96 h LC50 i.e., 0.03 mg l−1 (low concentration) and 0.07 mg l−1 (high concentration), respectively, were used for exposure. Blood, liver and kidney tissues of the control and exposed specimens were sampled at intervals of 15, 30, and 45 days to assess alterations in oxidative stress, genotoxicity haematological parameters and histopathology. Significant changes in Hb%, RBC count, WBC count, antioxidant enzyme activity, i.e., superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione reductase (GR), were recorded. Micronuclei (MN) induction, nuclear abnormalities (NAs) and histopathological alterations were also observed in the exposed fish. Significant (P 
ISSN:0022-1112
1095-8649
DOI:10.1111/jfb.15019