Gallic acid protects against isoproterenol-induced cardiotoxicity in rats

Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in...

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Published in:Human & experimental toxicology 2022-01, Vol.41, p.9603271211064532-9603271211064532
Main Authors: Shackebaei, Dareuosh, Hesari, Mahvash, Ramezani-Aliakbari, Soudabeh, Hoseinkhani, Zohreh, Ramezani-Aliakbari, Fatemeh
Format: Article
Language:English
Subjects:
Animal models
Ca2+-transporting ATPase
Calcium (reticular)
Calcium ions
Cardiac muscle
Cardiotoxicity
Cardiovascular system
Creatine
Creatine kinase
Damage
Gallic acid
Gene expression
Heart
Hemodynamics
Hypertrophy
Ischemia
Isoproterenol
Kinases
L-Lactate dehydrogenase
Lactate dehydrogenase
Reperfusion
Sarcoplasmic reticulum
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Summary:Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. Methods Male Wistar rats were randomly assigned into six groups: Control, Control treated with GA at 25 mg/kg (GA25), Control treated with GA at 50 mg/kg (GA50), Hypertrophic rats induced by ISO (ISO), Hypertrophic rats treated with GA at 25 mg/kg (ISO+GA25), and Hypertrophic rats treated with GA at 50 mg/kg (ISO+GA50). Heart isolation was performed to induce a cardiac I/R injury model. Cardiac hemodynamic parameters were recorded. Serum Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) and cardiac Superoxide dismutases (SOD) levels were evaluated. The gene expression of Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) was assessed. Results We found that GA at 50 mg/kg was significantly increased cardiac function at post I/R period in ISO-induced hypertrophic hearts. Moreover, it suppressed cardiac hypertrophy, the serum LDH and CK-MB levels in ISO injected rats. Administration of GA at 50 mg/kg was significantly increased SOD level and SERCA2a gene expression in the hypertrophic hearts. Conclusion GA at 50 mg/kg could improve cardiac performance possibly by increasing antioxidant defense enzymes, reducing cell damage, and enhancing SERCA2a gene expression in hypertrophic heart induced by ISO in I/R injury conditions.
ISSN:0960-3271
1477-0903
DOI:10.1177/09603271211064532