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Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching
Objectives Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H 2 O 2 ), applied for different time intervals, on enamel coated or not with polymeric biomaterials. Materials and methods Nanofiber scaffolds (NSc) and a primer catalyst (...
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| Published in: | Clinical oral investigations 2022-05, Vol.26 (5), p.4099-4108 |
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| container_title | Clinical oral investigations |
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| creator | Ortecho-Zuta, Uxua de Oliveira Duque, Carla Caroline de Oliveira Ribeiro, Rafael Antonio Leite, Maria Luísa Soares, Diana Gabriela Hebling, Josimeri Briso, André Luiz Fraga de Souza Costa, Carlos Alberto |
| description | Objectives
Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H
2
O
2
), applied for different time intervals, on enamel coated or not with polymeric biomaterials.
Materials and methods
Nanofiber scaffolds (NSc) and a primer catalyst (PrCa) were used to coat the bovine enamel/dentin discs before the application of BG-35%H
2
O
2
, according to the following groups: G1—negative control (NC, without treatment); G2, G3, and G4—BG-35%H
2
O
2
applied for 3 × 15, 2 × 15, and 15 min; G5, G6, and G7—BG-35%H
2
O
2
applied on enamel coated with NSc and PrCa for 3 × 15; 2 × 15, and 15 min, respectively. The culture medium with components of gel diffused through the discs was applied on MDPC-23 cells, which were evaluated regarding to viability (VB), integrity of the membrane (IM), and oxidative stress (OxS). The quantity of H
2
O
2
diffused and esthetic efficacy (Δ
E
/Δ
WI
) of the dental tissues were also analyzed (ANOVA/Tukey;
p
0.05). The lowest value of H
2
O
2
diffusion occurred in G4 and G7, where the cells exhibited the lowest OxS than G2 (
p
|
| doi_str_mv | 10.1007/s00784-022-04379-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2632803090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2659818626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-6f958d1e90f49e0feac28ae41d0c311b18690aeeb34f6d056972f6b64909a0fe3</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS1URMuUF2CBLLFhE7iOEydeVhV_UqUuoGvLca5nXCV2sR1B-jQ8C09WD1OgYtGNbel859wrH0JeMnjLALp3qRx9U0FdV9DwTla3T8gJa7ioeNexowfvY_I8pWsA1oiOPyPHvGVSMslPyPwlR51xu1IbIo04Lsb5LTVrDjn8cMbllWo_0jBk7fxewpR3mJ2haK0z2qz0u8s7ytpfP2fnabDU-SrsNaQj-qwnOkyoza6YT8lTq6eEL-7vDbn68P7r-afq4vLj5_Ozi8rwrs2VsLLtR4YSbCMRbHHXvcaGjWA4YwPrhQSNOPDGihFaIbvaikE0EqQuON-QN4fcmxi-LWVjNbtkcJq0x7AkVQte98BBQkFf_4dehyX6sl2hWtmXWYXekPpAmRhSimjVTXSzjqtioPZlqEMZqpShfpehbovp1X30Msw4_rX8-f0C8AOQiuS3GP_NfiT2DoQhluQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2659818626</pqid></control><display><type>article</type><title>Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching</title><source>Springer Link</source><creator>Ortecho-Zuta, Uxua ; de Oliveira Duque, Carla Caroline ; de Oliveira Ribeiro, Rafael Antonio ; Leite, Maria Luísa ; Soares, Diana Gabriela ; Hebling, Josimeri ; Briso, André Luiz Fraga ; de Souza Costa, Carlos Alberto</creator><creatorcontrib>Ortecho-Zuta, Uxua ; de Oliveira Duque, Carla Caroline ; de Oliveira Ribeiro, Rafael Antonio ; Leite, Maria Luísa ; Soares, Diana Gabriela ; Hebling, Josimeri ; Briso, André Luiz Fraga ; de Souza Costa, Carlos Alberto</creatorcontrib><description>Objectives
Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H
2
O
2
), applied for different time intervals, on enamel coated or not with polymeric biomaterials.
Materials and methods
Nanofiber scaffolds (NSc) and a primer catalyst (PrCa) were used to coat the bovine enamel/dentin discs before the application of BG-35%H
2
O
2
, according to the following groups: G1—negative control (NC, without treatment); G2, G3, and G4—BG-35%H
2
O
2
applied for 3 × 15, 2 × 15, and 15 min; G5, G6, and G7—BG-35%H
2
O
2
applied on enamel coated with NSc and PrCa for 3 × 15; 2 × 15, and 15 min, respectively. The culture medium with components of gel diffused through the discs was applied on MDPC-23 cells, which were evaluated regarding to viability (VB), integrity of the membrane (IM), and oxidative stress (OxS). The quantity of H
2
O
2
diffused and esthetic efficacy (Δ
E
/Δ
WI
) of the dental tissues were also analyzed (ANOVA/Tukey;
p
< 0.05).
Results
Only G7 was similar to G1 regarding VB (
p
> 0.05). The lowest value of H
2
O
2
diffusion occurred in G4 and G7, where the cells exhibited the lowest OxS than G2 (
p
< 0.05). Despite G5 showing the greatest Δ
E
regarding other groups (
p
< 0.05), the esthetic efficacy observed in G7 was similar to G2 (
p
> 0.05). Δ
WI
indicated a greater bleaching effect for groups G5, G6, and G7 (
p
< 0.05).
Conclusion
Coating the dental enamel with polymeric biomaterials reduced the time and the cytotoxicity of BG-35%H
2
O
2
.
Clinical significance.
Coating the dental enamel with polymeric biomaterials allows safer and faster BG-35%H
2
O
2
application.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-022-04379-z</identifier><identifier>PMID: 35199193</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biocompatible Materials ; Biomaterials ; Biomedical materials ; Bleaching ; Catalysts ; Cattle ; Cell culture ; Coatings ; Cytotoxicity ; Dental Enamel ; Dentin ; Dentistry ; Esthetics, Dental ; Hydrogen Peroxide ; Hypochlorous Acid ; Medicine ; Original Article ; Oxidative stress ; Tooth Bleaching ; Tooth Bleaching Agents - toxicity</subject><ispartof>Clinical oral investigations, 2022-05, Vol.26 (5), p.4099-4108</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6f958d1e90f49e0feac28ae41d0c311b18690aeeb34f6d056972f6b64909a0fe3</citedby><cites>FETCH-LOGICAL-c375t-6f958d1e90f49e0feac28ae41d0c311b18690aeeb34f6d056972f6b64909a0fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35199193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortecho-Zuta, Uxua</creatorcontrib><creatorcontrib>de Oliveira Duque, Carla Caroline</creatorcontrib><creatorcontrib>de Oliveira Ribeiro, Rafael Antonio</creatorcontrib><creatorcontrib>Leite, Maria Luísa</creatorcontrib><creatorcontrib>Soares, Diana Gabriela</creatorcontrib><creatorcontrib>Hebling, Josimeri</creatorcontrib><creatorcontrib>Briso, André Luiz Fraga</creatorcontrib><creatorcontrib>de Souza Costa, Carlos Alberto</creatorcontrib><title>Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H
2
O
2
), applied for different time intervals, on enamel coated or not with polymeric biomaterials.
Materials and methods
Nanofiber scaffolds (NSc) and a primer catalyst (PrCa) were used to coat the bovine enamel/dentin discs before the application of BG-35%H
2
O
2
, according to the following groups: G1—negative control (NC, without treatment); G2, G3, and G4—BG-35%H
2
O
2
applied for 3 × 15, 2 × 15, and 15 min; G5, G6, and G7—BG-35%H
2
O
2
applied on enamel coated with NSc and PrCa for 3 × 15; 2 × 15, and 15 min, respectively. The culture medium with components of gel diffused through the discs was applied on MDPC-23 cells, which were evaluated regarding to viability (VB), integrity of the membrane (IM), and oxidative stress (OxS). The quantity of H
2
O
2
diffused and esthetic efficacy (Δ
E
/Δ
WI
) of the dental tissues were also analyzed (ANOVA/Tukey;
p
< 0.05).
Results
Only G7 was similar to G1 regarding VB (
p
> 0.05). The lowest value of H
2
O
2
diffusion occurred in G4 and G7, where the cells exhibited the lowest OxS than G2 (
p
< 0.05). Despite G5 showing the greatest Δ
E
regarding other groups (
p
< 0.05), the esthetic efficacy observed in G7 was similar to G2 (
p
> 0.05). Δ
WI
indicated a greater bleaching effect for groups G5, G6, and G7 (
p
< 0.05).
Conclusion
Coating the dental enamel with polymeric biomaterials reduced the time and the cytotoxicity of BG-35%H
2
O
2
.
Clinical significance.
Coating the dental enamel with polymeric biomaterials allows safer and faster BG-35%H
2
O
2
application.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Bleaching</subject><subject>Catalysts</subject><subject>Cattle</subject><subject>Cell culture</subject><subject>Coatings</subject><subject>Cytotoxicity</subject><subject>Dental Enamel</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Esthetics, Dental</subject><subject>Hydrogen Peroxide</subject><subject>Hypochlorous Acid</subject><subject>Medicine</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Tooth Bleaching</subject><subject>Tooth Bleaching Agents - toxicity</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS1URMuUF2CBLLFhE7iOEydeVhV_UqUuoGvLca5nXCV2sR1B-jQ8C09WD1OgYtGNbel859wrH0JeMnjLALp3qRx9U0FdV9DwTla3T8gJa7ioeNexowfvY_I8pWsA1oiOPyPHvGVSMslPyPwlR51xu1IbIo04Lsb5LTVrDjn8cMbllWo_0jBk7fxewpR3mJ2haK0z2qz0u8s7ytpfP2fnabDU-SrsNaQj-qwnOkyoza6YT8lTq6eEL-7vDbn68P7r-afq4vLj5_Ozi8rwrs2VsLLtR4YSbCMRbHHXvcaGjWA4YwPrhQSNOPDGihFaIbvaikE0EqQuON-QN4fcmxi-LWVjNbtkcJq0x7AkVQte98BBQkFf_4dehyX6sl2hWtmXWYXekPpAmRhSimjVTXSzjqtioPZlqEMZqpShfpehbovp1X30Msw4_rX8-f0C8AOQiuS3GP_NfiT2DoQhluQ</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Ortecho-Zuta, Uxua</creator><creator>de Oliveira Duque, Carla Caroline</creator><creator>de Oliveira Ribeiro, Rafael Antonio</creator><creator>Leite, Maria Luísa</creator><creator>Soares, Diana Gabriela</creator><creator>Hebling, Josimeri</creator><creator>Briso, André Luiz Fraga</creator><creator>de Souza Costa, Carlos Alberto</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20220501</creationdate><title>Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching</title><author>Ortecho-Zuta, Uxua ; de Oliveira Duque, Carla Caroline ; de Oliveira Ribeiro, Rafael Antonio ; Leite, Maria Luísa ; Soares, Diana Gabriela ; Hebling, Josimeri ; Briso, André Luiz Fraga ; de Souza Costa, Carlos Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6f958d1e90f49e0feac28ae41d0c311b18690aeeb34f6d056972f6b64909a0fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Bleaching</topic><topic>Catalysts</topic><topic>Cattle</topic><topic>Cell culture</topic><topic>Coatings</topic><topic>Cytotoxicity</topic><topic>Dental Enamel</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Esthetics, Dental</topic><topic>Hydrogen Peroxide</topic><topic>Hypochlorous Acid</topic><topic>Medicine</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Tooth Bleaching</topic><topic>Tooth Bleaching Agents - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortecho-Zuta, Uxua</creatorcontrib><creatorcontrib>de Oliveira Duque, Carla Caroline</creatorcontrib><creatorcontrib>de Oliveira Ribeiro, Rafael Antonio</creatorcontrib><creatorcontrib>Leite, Maria Luísa</creatorcontrib><creatorcontrib>Soares, Diana Gabriela</creatorcontrib><creatorcontrib>Hebling, Josimeri</creatorcontrib><creatorcontrib>Briso, André Luiz Fraga</creatorcontrib><creatorcontrib>de Souza Costa, Carlos Alberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortecho-Zuta, Uxua</au><au>de Oliveira Duque, Carla Caroline</au><au>de Oliveira Ribeiro, Rafael Antonio</au><au>Leite, Maria Luísa</au><au>Soares, Diana Gabriela</au><au>Hebling, Josimeri</au><au>Briso, André Luiz Fraga</au><au>de Souza Costa, Carlos Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>26</volume><issue>5</issue><spage>4099</spage><epage>4108</epage><pages>4099-4108</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
Evaluate in vitro the esthetic efficacy and cytotoxicity of a bleaching gel containing 35% hydrogen peroxide (BG-35%H
2
O
2
), applied for different time intervals, on enamel coated or not with polymeric biomaterials.
Materials and methods
Nanofiber scaffolds (NSc) and a primer catalyst (PrCa) were used to coat the bovine enamel/dentin discs before the application of BG-35%H
2
O
2
, according to the following groups: G1—negative control (NC, without treatment); G2, G3, and G4—BG-35%H
2
O
2
applied for 3 × 15, 2 × 15, and 15 min; G5, G6, and G7—BG-35%H
2
O
2
applied on enamel coated with NSc and PrCa for 3 × 15; 2 × 15, and 15 min, respectively. The culture medium with components of gel diffused through the discs was applied on MDPC-23 cells, which were evaluated regarding to viability (VB), integrity of the membrane (IM), and oxidative stress (OxS). The quantity of H
2
O
2
diffused and esthetic efficacy (Δ
E
/Δ
WI
) of the dental tissues were also analyzed (ANOVA/Tukey;
p
< 0.05).
Results
Only G7 was similar to G1 regarding VB (
p
> 0.05). The lowest value of H
2
O
2
diffusion occurred in G4 and G7, where the cells exhibited the lowest OxS than G2 (
p
< 0.05). Despite G5 showing the greatest Δ
E
regarding other groups (
p
< 0.05), the esthetic efficacy observed in G7 was similar to G2 (
p
> 0.05). Δ
WI
indicated a greater bleaching effect for groups G5, G6, and G7 (
p
< 0.05).
Conclusion
Coating the dental enamel with polymeric biomaterials reduced the time and the cytotoxicity of BG-35%H
2
O
2
.
Clinical significance.
Coating the dental enamel with polymeric biomaterials allows safer and faster BG-35%H
2
O
2
application.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35199193</pmid><doi>10.1007/s00784-022-04379-z</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2022-05, Vol.26 (5), p.4099-4108 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2632803090 |
| source | Springer Link |
| subjects | Animals Biocompatible Materials Biomaterials Biomedical materials Bleaching Catalysts Cattle Cell culture Coatings Cytotoxicity Dental Enamel Dentin Dentistry Esthetics, Dental Hydrogen Peroxide Hypochlorous Acid Medicine Original Article Oxidative stress Tooth Bleaching Tooth Bleaching Agents - toxicity |
| title | Strategy for reducing cytotoxicity and obtaining esthetic efficacy with 15 min of in-office dental bleaching |
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