Trends in Prescribing Antipsychotics for Children and Adolescents in Japan: A Descriptive Epidemiological Study Using a Large-Scale Pharmacy Dataset

Little is known about antipsychotic prescription patterns among children and adolescents in Japan, particularly in outpatient settings. We investigated the prevalence and trends of antipsychotic prescription for outpatients aged ≤ 17 years receiving a first antipsychotic prescription from 2006 to 20...

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Bibliographic Details
Published in:Child psychiatry and human development 2023-10, Vol.54 (5), p.1250-1257
Main Authors: Nakane, Sayuri, Tanaka-Mizuno, Sachiko, Nishiyama, Chika, Kochi, Kenji, Yamamoto-Sasaki, Madoka, Takeuchi, Masato, Ogawa, Yusuke, Doi, Yuko, Arai, Masaru, Fujii, Yosuke, Matsunaga, Toshiyuki, Furukawa, Toshiaki A., Kawakami, Koji
Format: Article
Language:English
Subjects:
Adolescents
Age groups
Antipsychotics
Aripiprazole
Autism
Behavioral Science and Psychology
Child & adolescent psychiatry
Child and School Psychology
Child psychology
Datasets
Dosage
Drug dosages
Epidemiology
Males
Medical diagnosis
Medicine
Olanzapine
Original Article
Outpatients
Pediatrics
Pharmacy
Prescribing
Prescription drugs
Psychiatry
Psychology
Psychotropic drugs
Public health
Regression analysis
Risperidone
Schizophrenia
Second generation
Teenagers
Trends
University graduates
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Summary:Little is known about antipsychotic prescription patterns among children and adolescents in Japan, particularly in outpatient settings. We investigated the prevalence and trends of antipsychotic prescription for outpatients aged ≤ 17 years receiving a first antipsychotic prescription from 2006 to 2012 based on a large-scale dispensation dataset. Measurements included age, sex, department of diagnosis and treatment, type of prescription (monotherapy or polytherapy), antipsychotic dosage, and concomitant psychotropic drugs. Of the 10,511 patients, 65.1% were aged 13–17 years, and 52.9% were males. Second-generation antipsychotic monotherapy prescriptions increased from 53.8% in 2006 to 78.3% in 2012. Risperidone was the most frequently prescribed antipsychotic, followed by aripiprazole and olanzapine. Approximately 25.0% of patients were prescribed an initial dose less than recommended. Second-generation antipsychotic monotherapy is currently the most frequent prescription pattern among outpatients aged ≤ 17 years receiving an initial antipsychotic prescription.
ISSN:0009-398X
1573-3327
DOI:10.1007/s10578-022-01330-x