Lactobacillus bloodstream infections genetically related to probiotic use in pediatric hematopoietic cell transplant patients

We describe a cluster of 6 pediatric hematopoietic cell transplant recipients with Lactobacillus bacteremia attributed to probiotic use. Lactobacillus isolates cultured from probiotics and patients’ blood were proven to be related using whole-genome sequencing. Clinical studies are needed to evaluat...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2023-03, Vol.44 (3), p.484-487
Main Authors: Gilliam, Craig H., Brazelton de Cardenas, Jessica, Carias, Delia, Maron Alfaro, Gaby, Hayden, Randall T., Hakim, Hana
Format: Article
Language:English
Subjects:
Bacteremia - prevention & control
Catheters
Child
Concise Communication
Dietary supplements
Drug dosages
FDA approval
Fever
Genomes
Graft versus host disease
Hematopoietic Stem Cell Transplantation - adverse effects
Hospitalization
Humans
Immunocompromised Host
Infections
Laboratories
Lactobacillus - genetics
Leukemia
Mucositis
Multidrug resistant organisms
Neutropenia
Patients
Pediatrics
Penicillin
Probiotics
Probiotics - therapeutic use
Sepsis
Stem cell transplantation
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Summary:We describe a cluster of 6 pediatric hematopoietic cell transplant recipients with Lactobacillus bacteremia attributed to probiotic use. Lactobacillus isolates cultured from probiotics and patients’ blood were proven to be related using whole-genome sequencing. Clinical studies are needed to evaluate the safety of probiotic use in immunocompromised patients.
ISSN:0899-823X
1559-6834
DOI:10.1017/ice.2021.515