Different histone deacetylase inhibitors reduce growth, virulence as well as changes in the morphology of the fungus Macrophomina phaseolina (Tassi) Goid

Fungal phytopathogens require different skills to infect plants and complete their lifecycle. Some proteins in fungi are essential for pathogenesis and their expression is regulated by epigenetic mechanisms via chromatin-remodeling. Macrophomina phaseolina is an important phytopathogenic fungus that...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2022-04, Vol.38 (4), p.63-63, Article 63
Main Authors: Ramos-García, Víctor Hugo, Villota-Salazar, Nubia Andrea, González-Prieto, Juan Manuel, Cortés-Espinosa, Diana V.
Format: Article
Language:English
Subjects:
Applied Microbiology
Ascomycota - physiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Carbon sources
Chromatin remodeling
Deacetylation
Drought
Environmental Engineering/Biotechnology
Epigenetics
Fungi
Histone deacetylase
Histone Deacetylase Inhibitors - pharmacology
Histones
Inhibitors
Life Sciences
Macrophomina phaseolina
Microbiology
Morphology
Mycelia
Mycelium
Original Paper
Pathogenesis
Phytopathogenic fungi
Pigmentation
Sodium butyrate
Valproic acid
Virulence
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Summary:Fungal phytopathogens require different skills to infect plants and complete their lifecycle. Some proteins in fungi are essential for pathogenesis and their expression is regulated by epigenetic mechanisms via chromatin-remodeling. Macrophomina phaseolina is an important phytopathogenic fungus that leads to considerable losses of different crops, especially during drought conditions. Some biological features of the fungus have been described. However, the epigenetics mechanisms involved in the development and virulence of M. phaseolina have not been fully studied. In this work, chemical inhibition was used to evaluate the role of histone deacetylases (HDACs) in the biology of M. phaseolina . The effect of two histone deacetylase inhibitors (iHDAC), valproic acid (VPA) and sodium butyrate (SBT), was analyzed. The results showed that the treated fungus presented a decrease in microsclerotia diameter, aerial mycelia production, vegetative growth, and cell pigmentation. In addition, VPA and SBT also affected the ability of the fungus to grow on complex carbon sources and virulence in the bean variety, BAT 477. Thus, it can be concluded that the alteration of histone deacetylation by VPA and SBT affects M. phaseolina growth, morphology, and virulence. Graphical abstract
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-022-03249-w